Zagadou Brissi, Chan Philemon, Ho Kevin, Shelley David
L-3 Applied Technologies, Inc., 10180 Barnes Canyon Rd., San Diego, CA 92121-5701, USA.
Hear Res. 2016 Dec;342:23-38. doi: 10.1016/j.heares.2016.02.017. Epub 2016 Mar 9.
The current impulse noise criteria for the protection against impulse noise injury do not incorporate an objective measure of hearing protection. A new biomechanically-based model has been developed based on improvement of the Auditory Hazard Assessment Algorithm for the Human (AHAAH) using the integrated cochlear energy (ICE) as the damage risk correlate (DRC). The model parameters have been corrected using the latest literature data. The anomalous dose-response inversion behavior of the AHAAH model was eliminated. The modeling results show that the annular ligament (AL) parameters are the dominant cause of the non-monotonic dose-response behavior of AHAAH. Based on parametric optimization analysis, a 40% reduction of the AL compliance from the AHAAH default value removed the dose-response inversion problem, and this value was found to be within the physiological range when compared with experimental data. The transfer functions from the new model are in good agreement with those of the human ear. A dose-response curve based on ICE was developed using the human walk-up temporary threshold shift (TTS) data. Furthermore, the ICE values calculated for the German rifle noise tests show excellent comparison with the injury outcomes, hence providing a significant independent validation of the improved model. The ICE was found to be the best DRC to both large weapons and small arms noise injury data, covering both protected and unprotected exposures, respectively. The new AHAAH model with ICE as the dose metric is adequate for use as a medical standard against impulse noise injury.
当前用于预防脉冲噪声损伤的脉冲噪声标准并未纳入听力保护的客观衡量指标。基于人类听觉危险评估算法(AHAAH)的改进,利用整合的耳蜗能量(ICE)作为损伤风险关联指标(DRC),开发了一种新的基于生物力学的模型。已使用最新文献数据对模型参数进行了校正。消除了AHAAH模型异常的剂量反应倒置行为。建模结果表明,环形韧带(AL)参数是AHAAH非单调剂量反应行为的主要原因。基于参数优化分析,将AL顺应性从AHAAH默认值降低40%消除了剂量反应倒置问题,与实验数据相比,该值处于生理范围内。新模型的传递函数与人类耳朵的传递函数高度吻合。利用人类的步进式临时阈移(TTS)数据绘制了基于ICE的剂量反应曲线。此外,针对德国步枪噪声测试计算出的ICE值与损伤结果具有极佳的可比性,从而为改进后的模型提供了重要的独立验证。结果发现ICE是针对大口径武器和小口径武器噪声损伤数据的最佳DRC,分别涵盖了受保护和未受保护的暴露情况。以ICE作为剂量指标的新AHAAH模型足以用作预防脉冲噪声损伤的医学标准。