Wu Wen-Ming, Liu Ye, Chen Xu, Jin An, Zhou Ming, Tian Tian, Ruan Han-Li
Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hangkonglu 13, Wuhan 430030, People's Republic of China.
Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hangkonglu 13, Wuhan 430030, People's Republic of China.
Fitoterapia. 2016 Apr;110:123-8. doi: 10.1016/j.fitote.2016.03.008. Epub 2016 Mar 9.
Five new abietane diterpenoids, named abifadines A-E (1-5), and nine known ones (6-14), together with two known podocarpenes (15 and 16), were isolated from the branch and leaf of Abies fargesii. Their structures including the relative configurations were established on the basis of extensive spectroscopic analyses. The absolute configuration of 1 was determined through single-crystal X-ray diffraction analysis with Cu Kα irradiation. All the isolates were evaluated for their in vitro cytotoxicities. Only compounds 5 and 12 exhibited weak anti-proliferative effects against three cancer cell lines (B16, MCF7, and HepG2) with IC50 values range from 14.8 to 42.8 μM. The antimicrobial activities against Staphylococcus aureus, Escherichia coli and Monilia albicans of all compounds were also tested, but none of them showed significant activities.
从巴山冷杉的枝叶中分离得到了5个新的枞烷二萜类化合物，命名为冷杉二萜A - E（1 - 5），9个已知化合物（6 - 14），以及2个已知的罗汉松烯类化合物（15和16）。基于广泛的光谱分析确定了它们的结构，包括相对构型。通过Cu Kα辐射的单晶X射线衍射分析确定了1的绝对构型。对所有分离物进行了体外细胞毒性评估。只有化合物5和12对三种癌细胞系（B16、MCF7和HepG2）表现出较弱的抗增殖作用，IC50值范围为14.8至42.8 μM。还测试了所有化合物对金黄色葡萄球菌、大肠杆菌和白色念珠菌的抗菌活性，但均未显示出显著活性。
