Liñares Antonio, Grize Leticia, Muñoz Fernando, Pippenger Benjamin Evans, Dard Michel, Domken Olivier, Blanco-Carrión Juan
Periodontology Unit, School of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain.
Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland.
J Clin Periodontol. 2016 Jun;43(6):538-46. doi: 10.1111/jcpe.12543. Epub 2016 May 2.
The aim of this study was to investigate clinical and soft/hard tissues histomorphological outcomes of a ceramic implant comparatively to a titanium implant in a minipig model.
Eighteen soft tissue level implants (9 Ceramic with ZLA(®) surface as test, and 9 titanium SLActive(®) as control, Institut Straumann, Basel, Switzerland) were randomly placed into the mandible of 6 minipigs (n = 6). Two months later, animals were sacrificed and block biopsies were obtained to assess histomorphological outcomes. Unadjusted paired comparisons, of both groups were performed using the Wilcoxon signed rank test. The Dunnett-Hsu test was used to adjust for multiple comparisons.
All implants showed excellent integration into bone and soft tissue. The fBIC (distance implant shoulder to most coronal implant contact) and BIC% (percentage bone-to-implant contact) were for both groups; test: 3.95 mm and 85.4%; control 3.97 mm and 84.3% respectively. No difference in peri-implant mucosa height was found, however, the sulcular epithelium was significantly shorter for the ZrO2 (mean: 0.76, 95%CI: 0.46-1.06) than for the Ti (mean: 1.40, 95%CI: 1.10-1.70) (p = 0.0090).
Within the limits of this pilot study, no difference was found between the ceramic implant with ZLA(®) surface and a titanium implant in terms of bone tissue integration. Furthermore, the epithelial attachment favoured this ceramic implant over titanium.
本研究旨在比较在小型猪模型中，陶瓷种植体与钛种植体的临床及软硬组织组织形态学结果。
将18枚软组织水平种植体（9枚具有ZLA(®)表面的陶瓷种植体作为试验组，9枚钛SLActive(®)种植体作为对照组，瑞士巴塞尔的士卓曼公司）随机植入6只小型猪的下颌骨（n = 6）。两个月后，处死动物并获取块状活检组织以评估组织形态学结果。两组的未调整配对比较采用Wilcoxon符号秩检验。使用Dunnett-Hsu检验进行多重比较的调整。
所有种植体均显示出良好的骨和软组织整合。两组的种植体肩部至最冠方种植体接触点的距离（fBIC）和骨与种植体接触百分比（BIC%）分别为：试验组：3.95 mm和85.4%；对照组：3.97 mm和84.3%。种植体周围黏膜高度无差异，然而，ZrO2组的龈沟上皮明显短于Ti组（平均值：0.76，95%CI：0.46 - 1.06），而Ti组为（平均值：1.40，95%CI：1.10 - 1.70）（p = 0.0090）。
在本初步研究的范围内，具有ZLA(®)表面的陶瓷种植体与钛种植体在骨组织整合方面没有差异。此外，上皮附着更有利于这种陶瓷种植体而非钛种植体。
