Chopra Divya, Jayasree Anjana, Guo Tianqi, Gulati Karan, Ivanovski Sašo
The University of Queensland, School of Dentistry, Herston QLD, 4006, Australia.
Bioact Mater. 2021 Nov 5;13:161-178. doi: 10.1016/j.bioactmat.2021.10.010. eCollection 2022 Jul.
Zirconium-based implants have gained popularity in the dental implant field owing to their corrosion resistance and biocompatibility, attributed to the formation of a native zirconia (ZrO) film. However, enhanced bioactivity and local therapy from such implants are desirable to enable the earlier establishment and improved long-term maintenance of implant integration, especially in compromised patient conditions. As a result, surface modification of zirconium-based implants have been performed using various physical, chemical and biological techniques at the macro-, micro-, and nano-scales. In this extensive review, we discuss and detail the development of Zr implants covering the spectrum from past and present advancements to future perspectives, arriving at the next generation of highly bioactive and therapeutic nano-engineered Zr-based implants. The review provides in-depth knowledge of the bioactive/therapeutic value of surface modification of Zr implants in dental implant applications focusing on clinical translation.
基于锆的植入物因其耐腐蚀性和生物相容性而在牙种植领域受到欢迎，这归因于天然氧化锆（ZrO）膜的形成。然而，此类植入物增强的生物活性和局部治疗作用对于实现种植体整合的早期建立和改善长期维持是很有必要的，尤其是在患者情况不佳时。因此，已使用各种物理、化学和生物技术在宏观、微观和纳米尺度上对基于锆的植入物进行表面改性。在这篇全面的综述中，我们讨论并详细阐述了锆植入物的发展，涵盖从过去和现在的进展到未来前景的各个方面，从而引出下一代具有高生物活性和治疗作用的纳米工程化锆基植入物。这篇综述提供了关于锆植入物表面改性在牙种植应用中的生物活性/治疗价值的深入知识，重点关注临床转化。
