Kawata Ariane K, Wilson Hilary, Ong Siew Hwa, Kulich Karoly, Coyne Karin
Outcomes Research, Evidera, 7101 Wisconsin Avenue Suite 1400, Bethesda, MD, 20814, USA.
Novartis Pharma AG, Basel, Switzerland.
Patient. 2016 Oct;9(5):395-407. doi: 10.1007/s40271-016-0163-2.
The aim of this study was to evaluate the factor structure and psychometric characteristics of the Hypoglycemia Perspectives Questionnaire (HPQ) assessing experience and perceptions of hypoglycemia in patients with type 2 diabetes mellitus (T2DM).
HPQ was administered to adults with T2DM in a clinical sample from Cyprus (HYPO-Cyprus, n = 500) and a community sample in the United States (US, n = 1257) from the 2011 US National Health and Wellness Survey. Demographic and clinical data were collected. Analysis of HPQ data from two convenience samples examined item performance, factor structure, and HPQ measurement properties (reliability, convergent validity, known-groups validity).
Analyses supported three HPQ domains: symptom concern (six items), compensatory behavior (five items), and worry (five items). Internal consistency was high for all three domains (all ≥0.75), supporting reliability. Convergent validity was supported by moderate Spearman correlations between HPQ domain scores and the Audit of Diabetes-Dependent Quality of Life (ADDQoL-19) total score. Patients with recent hypoglycemia events had significantly higher HPQ scores, supporting known-group validity.
HPQ may be a valid and reliable measure capturing the experience and impact of hypoglycemia and useful in clinical trials and community-based settings.
本研究旨在评估低血糖认知问卷（HPQ）的因子结构和心理测量学特征，该问卷用于评估2型糖尿病（T2DM）患者的低血糖经历和认知。
对来自塞浦路斯的临床样本（HYPO-塞浦路斯，n = 500）中的成年T2DM患者以及来自2011年美国国家健康与健康调查的美国社区样本（n = 1257）进行HPQ问卷调查。收集人口统计学和临床数据。对两个便利样本的HPQ数据进行分析，以检验项目表现、因子结构和HPQ测量属性（信度、收敛效度、已知群体效度）。
分析支持HPQ的三个领域：症状关注（6项）、代偿行为（5项）和担忧（5项）。所有三个领域的内部一致性都很高（均≥0.75），支持信度。HPQ领域得分与糖尿病相关生活质量评估（ADDQoL-19）总分之间的中度斯皮尔曼相关性支持收敛效度。近期有低血糖事件的患者HPQ得分显著更高，支持已知群体效度。
HPQ可能是一种有效且可靠的测量工具，可捕捉低血糖的经历和影响，在临床试验和社区环境中有用。
