通过内镜空间分辨反射测量法进行组织光学特性的临床测定。
Clinical determination of tissue optical properties by endoscopic spatially resolved reflectometry.
作者信息
Bays R, Wagnières G, Robert D, Braichotte D, Savary J F, Monnier P, van den Bergh H
出版信息
Appl Opt. 1996 Apr 1;35(10):1756-66. doi: 10.1364/AO.35.001756.
PMID:21085299
Abstract
A noninvasive method to measure the optical properties of a diffusing and absorbing medium is described. Based on the spatially resolved measurement of diffuse reflectance at the sample surface, this method is particularly suitable for investigating the in vivo optical properties of biological tissues endoscopically in a clinical context. The sensitivity of the measurement is discussed, and two optical probes for two different clinical applications are presented. Preliminary measurements are performed on a nonbiological medium, which illustrate the possibilities of the proposed method. Finally, we report on in vivo measurements of the optical properties of the human esophageal wall at 630 nm.
摘要
描述了一种测量散射和吸收介质光学特性的非侵入性方法。基于对样品表面漫反射的空间分辨测量，该方法特别适用于在临床环境中通过内窥镜研究生物组织的体内光学特性。讨论了测量的灵敏度，并介绍了用于两种不同临床应用的两种光学探头。在非生物介质上进行了初步测量，这些测量说明了所提出方法的可能性。最后，我们报告了在630nm波长下对人体食管壁光学特性的体内测量结果。
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