Bucci Laura, Ostan Rita, Cevenini Elisa, Pini Elisa, Scurti Maria, Vitale Giovanni, Mari Daniela, Caruso Calogero, Sansoni Paolo, Fanelli Flaminia, Pasquali Renato, Gueresi Paola, Franceschi Claudio, Monti Daniela
Department of Experimental, Diagnostic and Specialty Medicine (DIMES) and Interdepartmental Centre "L. Galvani" (CIG), University of Bologna, 40126 Bologna, Italy.
Department of Clinical Sciences and Community Health (DISCCO), University of Milan, 20122 Milan, Italy.
Aging (Albany NY). 2016 Mar;8(3):510-9. doi: 10.18632/aging.100912.
Within the scenario of an increasing life expectancy worldwide it is mandatory to identify determinants of healthy aging. Centenarian offspring (CO) is one of the most informative model to identify trajectories of healthy aging and their determinants (genetic and environmental), being representative of elderly in their 70th whose lifestyle can be still modified to attain a better health. This study is the first comprehensive investigation of the health status of 267 CO (mean age: 70.2 years) and adopts the innovative approach of comparing CO with 107 age-matched offspring of non-long-lived parents (hereafter indicated as NCO controls), recruited according to strict inclusion demographic criteria of Italian population. We adopted a multidimensional approach which integrates functional and cognitive assessment together with epidemiological and clinical data, including pro- and anti-inflammatory cytokines and adipokines, lipid profile, and insulin resistance. CO have a lower prevalence of stroke, cerebral thrombosis-hemorrhage, hypertension, hypercholesterolemia, and other minor diseases, lower BMI and waist circumference, a better functional and cognitive status and lower plasma level of FT4 compared to NCO controls. We conclude that a multidimensional approach is a reliable strategy to identify the health status of elderly at an age when interventions to modify their health trajectory are feasible.
在全球预期寿命不断增加的背景下，确定健康老龄化的决定因素至关重要。百岁老人的后代（CO）是识别健康老龄化轨迹及其决定因素（遗传和环境）的最具信息价值的模型之一，代表了70岁的老年人，其生活方式仍可改变以获得更好的健康。本研究首次对267名CO（平均年龄：70.2岁）的健康状况进行了全面调查，并采用了创新方法，将CO与107名年龄匹配的非长寿父母的后代（以下简称NCO对照）进行比较，这些对照是根据意大利人群严格的纳入人口统计学标准招募的。我们采用了一种多维度方法，将功能和认知评估与流行病学和临床数据相结合，包括促炎和抗炎细胞因子、脂肪因子、血脂谱和胰岛素抵抗。与NCO对照相比，CO患中风、脑血栓形成-出血、高血压、高胆固醇血症和其他轻微疾病的患病率较低，BMI和腰围较低，功能和认知状态较好，血浆FT4水平较低。我们得出结论，多维度方法是一种可靠的策略，可用于识别在可对其健康轨迹进行干预的年龄阶段老年人的健康状况。
