一种新的羽扇豆烷型三萜脂肪酸酯及其他从滇南蛇根草中分离得到的化合物。
A new lupane-type triterpenoid fatty acid ester and other isolates from Ophiorrhiza shendurunii.
作者信息
Rajan Renjith, Venkataraman Ramaswamy, Baby Sabulal
机构信息
a Phytochemistry and Phytopharmacology Division , Jawaharlal Nehru Tropical Botanic Garden and Research Institute , Thiruvananthapuram , India.
b Department of Chemistry, Sri Paramakalyani College , Manonmaniom Sundaranar University , Tirunelveli , India.
出版信息
Nat Prod Res. 2016 Oct;30(19):2197-203. doi: 10.1080/14786419.2016.1160232. Epub 2016 Mar 16.
A new pentacyclic triterpenoid fatty acid ester, lupan-20-ol-3(β)-yl hexadecanoate (1), together with lupan-20-ol-3(β)-yl acetate (2), olean-18-en-3(β)-yl hexadecanoate (3), dotriacontanoic acid (4), stigmasterol (5), rubiadin (6), nonadecanoic acid (7), palmitic acid (8) and camptothecin (9) were isolated from the hexane and chloroform extracts of Ophiorrhiza shendurunii from South India. Structures of the isolates were determined by (1)H, (13)C, (13)C DEPT, (1)H-(1)H COSY, HMBC, HSQC, NOESY NMR, FT-IR, DART-MS, ESI-MS, alkaline hydrolysis, derivatisation, GC-MS and HPTLC analyses. O. shendurunii hexane and chloroform extracts showed significant activities against Candida albicans and Fusarium oxysporum. Compounds 1 to 3 showed only moderate antiyeast/antifungal activities.
从印度南部申杜鲁尼蛇根草的己烷和氯仿提取物中分离出一种新的五环三萜脂肪酸酯，十六烷酸羽扇豆-20-醇-3(β)-酯(1)，以及乙酸羽扇豆-20-醇-3(β)-酯(2)、十六烷酸齐墩果-18-烯-3(β)-酯(3)、三十二烷酸(4)、豆甾醇(5)、茜草素(6)、十九烷酸(7)、棕榈酸(8)和喜树碱(9)。通过(1)H、(13)C、(13)C DEPT、(1)H-(1)H COSY、HMBC、HSQC、NOESY NMR、FT-IR、DART-MS、ESI-MS、碱性水解、衍生化、GC-MS和HPTLC分析确定了分离物的结构。申杜鲁尼蛇根草的己烷和氯仿提取物对白色念珠菌和尖孢镰刀菌显示出显著活性。化合物1至3仅显示出中等程度的抗酵母/抗真菌活性。
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