Bahadoran Zahra, Mirmiran Parvin, Tahmasebinejad Zhaleh, Azizi Fereidoun
Student Research Office, Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran ; No. 24, Shahid-Erabi St., Yeman St., Velenjak, Tehran, Iran.
Nutr Metab (Lond). 2016 Mar 15;13:23. doi: 10.1186/s12986-016-0084-z. eCollection 2016.
We investigated the association of regular dietary intake of L-arginine and both the incidence of coronary heart disease (CHD) and changes of blood pressure.
Eligible adults (n = 2284) who participated in the Tehran Lipid and Glucose Study were followed for a mean of 4.7 years. Dietary intake of L-arginine was assessed at baseline (2006-2008); biochemical variables were evaluated at baseline and the follow-up examination. Multivariate Cox proportional hazard regression models adjusted for potential confounders were used to estimate the risk of CHD across tertiles of L-arginine intake. Linear regression models were also used to indicate the association of L-arginine intake with changes of serum lipids and blood pressure during the follow-up.
Mean age of participants (42.8 % men) was 38.2 ± 13.4, at baseline. During a mean 4.7 ± 1.4 y of follow-up, 57 participants experienced CHD events. A significant negative association was observed between plant-derived L-arginine intake and changes of both systolic and diastolic blood pressure, whereas animal-derived L-arginine intake was related to increased levels of diastolic blood pressure (P < 0.01). Participants in the 2(nd) tertile (1.45-1.78 g/d) had a significantly increased risk of CHD events compared to the participants in the 1(st) tertile (<1.45 g/d) (HR = 1.90, 95 % CI = 1.03-3.58). The risk of CHD had a decreasing trend across increasing plant-derived L-arginine intake (HR = 1.0, HR = 0.91, 95 % CI = 0.51-1.62, HR = 0.72, 95 % CI = 0.39-1.32, P for trend = 0.03).
Higher intake of plant derived L-arginine may have a protective effect whereas animal-derived L-arginine may be a risk factor for development of hypertension and CHD events.
我们研究了定期膳食摄入L-精氨酸与冠心病（CHD）发病率及血压变化之间的关联。
对参与德黑兰脂质与葡萄糖研究的符合条件的成年人（n = 2284）进行了平均4.7年的随访。在基线期（2006 - 2008年）评估L-精氨酸的膳食摄入量；在基线期和随访检查时评估生化变量。使用针对潜在混杂因素进行调整的多变量Cox比例风险回归模型来估计L-精氨酸摄入量三分位数组中冠心病的风险。线性回归模型也用于表明L-精氨酸摄入量与随访期间血脂和血压变化之间的关联。
参与者的平均年龄（42.8%为男性）在基线期为38.2±13.4岁。在平均4.7±1.4年的随访期间，57名参与者发生了冠心病事件。观察到植物来源的L-精氨酸摄入量与收缩压和舒张压变化之间存在显著负相关，而动物来源的L-精氨酸摄入量与舒张压水平升高有关（P < 0.01）。与第一三分位数组（<1.45 g/d）的参与者相比，第二三分位数组（1.45 - 1.78 g/d）的参与者发生冠心病事件的风险显著增加（HR = 1.90，95% CI = 1.03 - 3.58）。随着植物来源的L-精氨酸摄入量增加，冠心病风险呈下降趋势（HR = 1.0，HR = 0.91，95% CI = 0.51 - 1.62，HR = 0.72，95% CI = 0.39 - 1.32，趋势P值 = 0.03）。
较高的植物来源L-精氨酸摄入量可能具有保护作用，而动物来源的L-精氨酸可能是高血压和冠心病事件发生的一个风险因素。
