Kamoun Khaled, Sellami Tarak, Jlailia Zied, Abid Layla, Jenzri Mourad, Bouaziz Mouna, Zouar Omar
Orthopedic Pediatric Department, Kassab Institute, Tunis, Tunisia.
Anatomopathology Department, Kassab Institute, Tunis,Tunisia.
Pan Afr Med J. 2015 Dec 14;22:363. doi: 10.11604/pamj.2015.22.363.8309. eCollection 2015.
Giant cell reparative granuloma (GCRG) is a rare, benign intra osseous lytic lesion occurring especially in gnathis bone but also seen in feet and hands. It has similar clinical and radiological presentations than giant cell tumor, chondroblastoma, aneurysmal bone cyst, and hyperparathyroidism brown tumors but with specific histological findings We report a case of a GCRG of hallux phalanx in 18 years old patient appearing many years after enchondroma curettage and grafting. Radiographs showed a multiloculated osteolytic lesions involving whole phalanx with cortical thinning and without fluid-fluid levels in CT view. Expected to be an enchondroma recurrence, second biopsy confirmed diagnosis of GCRG with specific histological findings. Although if aetiopathogeny remains unknown, GCRG is reported to be a local non neoplasic reaction to an intraosseous hemorrhage. Our exceptional case claims that this tumor can appear in reaction to cellular disturbance primary or secondary.
巨细胞修复性肉芽肿（GCRG）是一种罕见的良性骨内溶解性病变，尤其好发于颌骨，但也可见于手足部位。它具有与巨细胞瘤、软骨母细胞瘤、动脉瘤样骨囊肿和甲状旁腺功能亢进棕色瘤相似的临床和影像学表现，但有特定的组织学特征。我们报告一例18岁患者拇趾近节趾骨的GCRG病例，该病例在软骨瘤刮除植骨多年后出现。X线片显示整个趾骨有多房性溶骨性病变，皮质变薄，CT检查未见液-液平面。最初预计为软骨瘤复发，再次活检通过特定的组织学特征确诊为GCRG。尽管其发病机制尚不清楚，但据报道GCRG是对骨内出血的一种局部非肿瘤性反应。我们这一特殊病例表明，这种肿瘤可因原发性或继发性细胞紊乱而出现。
