Sinha Archana, Lewis O'Dene, Kumar Rajan, Yeruva Sri Lakshmi Hyndavi, Curry Bryan H
Division of Cardiology, Saint Luke's University Health Network, 801 Ostrum Street, Bethlehem, PA 18015, USA.
Division of Pulmonary Medicine, Howard University Hospital, 2041 Georgia Avenue, Washington, DC 20060, USA.
Case Rep Cardiol. 2016;2016:7967851. doi: 10.1155/2016/7967851. Epub 2016 Feb 21.
Amphetamine abuse is a global problem. The cardiotoxic manifestations like acute myocardial infarction (AMI), heart failure, or arrhythmia related to misuse of amphetamine and its synthetic derivatives have been documented but are rather rare. Amphetamine-related AMI is even rarer. We report two cases of men who came to emergency department (ED) with chest pain, palpitation, or seizure and were subsequently found to have myocardial infarction associated with the use of amphetamines. It is crucial that, with increase in amphetamine abuse, clinicians are aware of this potentially dire complication. Patients with low to intermediate risk for coronary artery disease with atypical presentation may benefit from obtaining detailed substance abuse history and urine drug screen if deemed necessary.
苯丙胺滥用是一个全球性问题。与苯丙胺及其合成衍生物滥用相关的心脏毒性表现，如急性心肌梗死（AMI）、心力衰竭或心律失常已有文献记载，但相当罕见。与苯丙胺相关的AMI甚至更罕见。我们报告了两例男性患者，他们因胸痛、心悸或癫痫发作前来急诊科（ED），随后被发现患有与使用苯丙胺相关的心肌梗死。随着苯丙胺滥用情况的增加，临床医生意识到这种潜在的严重并发症至关重要。对于冠状动脉疾病风险低至中度且表现不典型的患者，如果认为有必要，获取详细的药物滥用史和尿液药物筛查可能会有所帮助。
