Alasmari Fawaz, Assiri Mohammed A, Ahamad Syed Rizwan, Aljumayi Sahar R, Alotaibi Wedad H, Alhamdan Majd M, Alhazzani Khalid, Alharbi Metab, Alqahtani Faleh, Alasmari Abdullah F
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Metabolites. 2022 Feb 14;12(2):179. doi: 10.3390/metabo12020179.
Studies have demonstrated that chronic consumption of abused drugs induces alterations in several proteins that regulate metabolism. For instance, methamphetamine exposure reduces glucose levels. Fatty and amino acid levels were altered in groups exposed to abused drugs. Therefore, in our study, we investigated the serum metabolomic profile of patients diagnosed with cannabis and/or amphetamine use disorders. Blood was obtained from subjects (control, amphetamine, and cannabis). Detection of serum metabolites was performed using gas chromatography. The ratio peak areas for metabolites were analyzed across the three groups. Both cannabis and amphetamine groups showed higher -erythrotetrafuranose, octadecanoic acid, hexadecenoic acid, trans-9-octadecanoic acid, lactic acid and methyl thio hydantoin metabolites compared with the control group. Moreover, cannabis patients were found to possess higher glycine, 9,12 octadecanoic acid malonic acid, phosphoric acid and prostaglandin F1a than controls. Our analysis showed that the identified metabolic profile of cannabis or amphetamine use disorder patients was different than control group. Our data indicated that chronic exposure to cannabis or amphetamine dysregulated metabolites in the serum. Future studies are warranted to explore the effects of these abused drugs on the metabolic proteins.
研究表明，长期滥用药物会导致几种调节新陈代谢的蛋白质发生改变。例如，接触甲基苯丙胺会降低血糖水平。接触滥用药物的组中脂肪酸和氨基酸水平发生了变化。因此，在我们的研究中，我们调查了被诊断患有大麻和/或苯丙胺使用障碍的患者的血清代谢组学特征。从受试者（对照组、苯丙胺组和大麻组）采集血液。使用气相色谱法检测血清代谢物。分析了三组中代谢物的峰面积比。与对照组相比，大麻组和苯丙胺组的赤藓糖、十八烷酸、十六碳烯酸、反式-9-十八烷酸、乳酸和甲基硫代乙内酰脲代谢物含量均较高。此外，发现大麻患者的甘氨酸、9,12-十八烷酸丙二酸、磷酸和前列腺素F1a含量高于对照组。我们的分析表明，已确定的大麻或苯丙胺使用障碍患者的代谢特征与对照组不同。我们的数据表明，长期接触大麻或苯丙胺会使血清中的代谢物失调。有必要开展进一步研究以探索这些滥用药物对代谢蛋白的影响。
