Cadmus-Bertram Lisa, Nelson Sandahl H, Hartman Sheri, Patterson Ruth E, Parker Barbara A, Pierce John P
Department of Kinesiology, University of Wisconsin - Madison, 2000 Observatory Drive, Madison, WI, 53706, USA.
Department of Family Medicine and Public Health, Moores UCSD Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, La Jolla, CA, 92093-0901, USA.
J Behav Med. 2016 Aug;39(4):551-9. doi: 10.1007/s10865-016-9735-9. Epub 2016 Mar 24.
Excess weight and physical inactivity are modifiable risk factors for breast cancer. Behavioral intervention is particularly important among women with an elevated risk profile. This trial tested an intervention that trained women to use a self-monitoring website to increase activity and lose weight. Women with BMI ≥27.5 kg/m(2) at elevated breast cancer risk were randomized to the intervention (N = 71) or usual care (N = 34). The intervention group received telephone-based coaching and used web-based self-monitoring tools. At 6 months, significant weight loss was observed in the intervention group (4.7 % loss from starting weight; SD = 4.7 %) relative to usual care (0.4 % gain; SD = 3.0 %) (p < 0.0001). By 12 months, the intervention group had lost 3.7 % of weight (SD = 5.4 %), compared to 1.3 % (SD = 4.2) for usual care (p = 0.003). At 12 months, accelerometer-measured moderate-to-vigorous physical activity increased by 12 min/day (SD = 24) compared to no change in usual care (p = 0.04. In summary, this web- and phone-based approach produced modest but significant improvements in weight and physical activity for women at elevated breast cancer risk.
超重和缺乏身体活动是乳腺癌可改变的风险因素。行为干预在风险较高的女性中尤为重要。本试验测试了一种干预措施，即培训女性使用自我监测网站来增加活动量和减轻体重。乳腺癌风险较高且BMI≥27.5 kg/m²的女性被随机分为干预组（N = 71）或常规护理组（N = 34）。干预组接受电话指导并使用基于网络的自我监测工具。6个月时，与常规护理组（体重增加0.4%；标准差=3.0%）相比，干预组观察到显著的体重减轻（较初始体重减轻4.7%；标准差=4.7%）（p<0.0001）。到12个月时，干预组体重减轻了3.7%（标准差=5.4%），而常规护理组为1.3%（标准差=4.2%）（p = 0.003）。12个月时，与常规护理组无变化相比，加速度计测量的中度至剧烈身体活动增加了12分钟/天（标准差=24）（p = 0.04）。总之，这种基于网络和电话的方法使乳腺癌风险较高的女性在体重和身体活动方面有适度但显著的改善。
