Carlstein Catrine, Marie Søes Lillian, Jørgen Christensen Jens
Department of Gynaecology and Obstetrics, Næstved Hospital, Ringstedgade 61, 4700 Næstved, Denmark.
Department of Clinical Microbiology, Slagelse Hospital, Ingemannsvej 18, 4200 Slagelse, Denmark.
Open Microbiol J. 2016 Mar 10;10:27-31. doi: 10.2174/1874285801610010027. eCollection 2016.
Chorioamnionitis is a potentially life threatening infection of the fetal membranes, commonly caused by ascending bacteria from the vagina and cervix. In our case, a healthy nullipara with a term pregnancy presented clinical signs of infection after induced labour with an intracervical balloon. Thick green and foul smelling amniotic fluid was observed and culture showed massive growth of Aerococcus christensenii, a facultative anaerob species found in the human vagina, previously only rarely alleged to cause invasive infection. Additional testing with 16S rRNA gene analysis also identified the presence of Gemella asaccharolytica, Snethia sanguinegens, P arvimonas micra and S treptobacillus moniliformis. The patient was treated with cefuroxime and metronidazole and recovered quickly. The newborn showed no signs of infection. This case points at the possible role of these pathogens in female genital tract infections. The case also underlines the importance of the combination of culture and culture independent diagnostic approaches to reveal possible polymicrobial natures of selected infections, in this case chorioamnionitis.
绒毛膜羊膜炎是一种可能危及生命的胎膜感染，通常由阴道和宫颈的上行细菌引起。在我们的病例中，一名足月妊娠的健康初产妇在使用宫颈球囊引产术后出现感染的临床症状。观察到羊水呈浓稠绿色且有恶臭，培养显示克里斯滕森气球菌大量生长，这是一种在人类阴道中发现的兼性厌氧菌，此前仅有极少病例称其可引起侵袭性感染。16S rRNA基因分析的进一步检测还发现了不解糖孪生球菌、血源嗜胨菌、微小单胞菌和念珠状链杆菌。患者接受头孢呋辛和甲硝唑治疗后迅速康复。新生儿未显示出感染迹象。该病例指出了这些病原体在女性生殖道感染中可能发挥的作用。该病例还强调了将培养与非培养诊断方法相结合以揭示特定感染（如本例中的绒毛膜羊膜炎）可能的多微生物性质的重要性。
