Santos Miguel, Filipe Elysse C, Michael Praveesuda L, Hung Juichien, Wise Steven G, Bilek Marcela M M
Applied Materials Group, The Heart Research Institute , 7 Eliza Street, Newtown, New South Wales 2042, Australia.
ACS Appl Mater Interfaces. 2016 Apr 20;8(15):9635-50. doi: 10.1021/acsami.6b01279. Epub 2016 Apr 5.
The long-term performance of many medical implants is limited by the use of inherently incompatible and bioinert materials. Metallic alloys, ceramics, and polymers commonly used in cardiovascular devices encourage clot formation and fail to promote the appropriate molecular signaling required for complete implant integration. Surface coating strategies have been proposed for these materials, but coronary stents are particularly problematic as the large surface deformations they experience in deployment require a mechanically robust coating interface. Here, we demonstrate a single-step ion-assisted plasma deposition process to tailor plasma-activated interfaces to meet current clinical demands for vascular implants. Using a process control-feedback strategy which predicts crucial coating growth mechanisms by adopting a suitable macroscopic plasma description in combination with noninvasive plasma diagnostics, we describe the optimal conditions to generate highly reproducible, industry-scalable stent coatings. These interfaces are mechanically robust, resisting delamination even upon plastic deformation of the underlying material, and were developed in consideration of the need for hemocompatibility and the capacity for biomolecule immobilization. Our optimized coating conditions combine the best mechanical properties with strong covalent attachment capacity and excellent blood compatibility in initial testing with plasma and whole blood, demonstrating the potential for improved vascular stent coatings.
许多医用植入物的长期性能受到固有不相容且生物惰性材料使用的限制。心血管装置中常用的金属合金、陶瓷和聚合物会促使血栓形成，并且无法促进植入物完全整合所需的适当分子信号传导。针对这些材料已提出了表面涂层策略，但冠状动脉支架尤其成问题，因为它们在展开过程中经历的大表面变形需要机械坚固的涂层界面。在此，我们展示了一种单步离子辅助等离子体沉积工艺，以定制等离子体活化界面，满足当前血管植入物的临床需求。通过采用合适的宏观等离子体描述结合非侵入性等离子体诊断来预测关键涂层生长机制的过程控制反馈策略，我们描述了生成高度可重复、可工业规模生产的支架涂层的最佳条件。这些界面机械坚固，即使在底层材料发生塑性变形时也能抵抗分层，并且是在考虑到血液相容性需求和生物分子固定能力的情况下开发的。我们优化的涂层条件在与血浆和全血的初步测试中结合了最佳机械性能、强共价附着能力和出色的血液相容性，证明了改进血管支架涂层的潜力。
