School of Molecular Bioscience, University of Sydney, NSW 2006, Australia.
Nanomedicine (Lond). 2012 Dec;7(12):1907-16. doi: 10.2217/nnm.12.161.
Polymeric and metallic materials are used extensively in permanently implanted cardiovascular devices and devices that make temporary but often prolonged contact with body fluids and tissues. Foreign body responses are typically triggered by host interactions at the implant surface, making surface modifications to increase biointegration desirable. Plasma-based treatments are extensively used to modify diverse substrates; modulating surface chemistry, wettability and surface roughness, as well as facilitating covalent biomolecule binding. Each aspect impacts on facets of vascular compatibility including endothelialization and blood contact. These modifications can be readily applied to polymers such as Dacron and expanded polytetrafluoroethylene, which are widely used in bypass grafting and the metallic substrates of stents, valves and pacemaker components. Plasma modification of metals is more challenging given the need for coating deposition in addition to surface activation, adding the necessity for robust interface adhesion. This review examines the evolving plasma treatment technology facilitating the biofunctionalization of polymeric and metallic implantable cardiovascular materials.
高分子和金属材料广泛应用于永久性植入式心血管装置和与体液及组织有临时但长期接触的装置中。异物反应通常由植入物表面的宿主相互作用引发，因此增加生物整合性的表面修饰是可取的。基于等离子体的处理方法广泛用于修饰各种基底，调节表面化学、润湿性和表面粗糙度，并促进共价生物分子结合。每一个方面都影响血管相容性的各个方面，包括内皮化和血液接触。这些修饰可以很容易地应用于聚合物，如涤纶和膨体聚四氟乙烯，它们广泛应用于旁路移植和支架、瓣膜和起搏器部件的金属基底。考虑到除了表面激活之外还需要涂层沉积，因此金属的等离子体改性更具挑战性，这增加了对坚固的界面附着力的需求。本文综述了不断发展的等离子体处理技术，该技术促进了可植入心血管高分子和金属材料的生物功能化。
