Voerman Ellis, Jaddoe Vincent W V, Gishti Olta, Hofman Albert, Franco Oscar H, Gaillard Romy
The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Obesity (Silver Spring). 2016 May;24(5):1170-7. doi: 10.1002/oby.21466. Epub 2016 Mar 26.
The associations of maternal caffeine intake during pregnancy with offspring growth patterns and body fat and insulin levels at school age were examined.
In a population-based birth cohort among 7,857 mothers and their children, maternal caffeine intake during pregnancy was assessed by questionnaires. Growth characteristics were measured from birth onward. At 6 years, body fat and insulin levels were measured.
Compared to children whose mothers consumed <2 units of caffeine per day during pregnancy (1 unit of caffeine is equivalent to 1 cup of coffee (90 mg caffeine)), those whose mothers consumed ≥6 units of caffeine per day tended to have a lower weight at birth, higher weight gain from birth to 6 years, and higher body mass index from 6 months to 6 years. Both children whose mothers consumed 4-5.9 and ≥6 units of caffeine per day during pregnancy tended to have a higher childhood body mass index and total body fat mass. Only children whose mothers consumed ≥6 units of caffeine per day had a higher android/gynoid fat mass ratio.
These results suggest that high levels of maternal caffeine intake during pregnancy are associated with adverse offspring growth patterns and childhood body fat distribution.
研究孕期母亲咖啡因摄入量与子代学龄期生长模式、体脂及胰岛素水平之间的关联。
在一项基于人群的出生队列研究中，对7857名母亲及其子女进行研究，通过问卷调查评估孕期母亲咖啡因摄入量。从出生起测量生长特征。在6岁时测量体脂和胰岛素水平。
与孕期母亲每天摄入咖啡因<2单位（1单位咖啡因相当于1杯咖啡（90毫克咖啡因））的儿童相比，孕期母亲每天摄入咖啡因≥6单位的儿童出生体重往往较低，出生至6岁体重增加较多，6个月至6岁时体重指数较高。孕期母亲每天摄入咖啡因4 - 5.9单位和≥6单位的儿童，儿童期体重指数和总体脂量往往都较高。只有孕期母亲每天摄入咖啡因≥6单位的儿童，其腹部/臀部脂肪量比值较高。
这些结果表明，孕期母亲高咖啡因摄入量与子代不良生长模式及儿童期体脂分布有关。
