Ayeser Tayfun, Basak Mesut, Arslan Kadem, Sayan Ismet
Tirebolu State Hospital, Tirebolu, Giresun, Turkey.
Yalova University, Yalova, Turkey.
Diabetes Metab Syndr. 2016 Apr-Jun;10(2 Suppl 1):S165-9. doi: 10.1016/j.dsx.2016.03.010. Epub 2016 Mar 12.
Cardiovascular diseases are among the leading causes of morbidity and mortality in developed countries. Metabolic syndrome is a common clinical presentation posing significant risk in cardiovascular diseases. This study investigated the correlation between the number of diagnostic criteria and serum adiponectin, leptin, resistin, TNF-alpha, EGFR levels and abdominal adipose tissue in the individuals with metabolic syndrome.
This study included a total of 40 patients (18 men and 22 women) with metabolic syndrome that applied to the Internal Diseases Outpatient Clinic of Ümraniye Training and Research Hospital between March 2011 and August 2011. The data including age, gender, personal history, familial history, habits, height, weight, systolic blood pressure, diastolic blood pressure, body mass index, waist circumference, hip circumference, body composition (tanita) were recorded for each patient. Blood samples were collected for biochemical examinations. The serum adiponectin, leptin, resistin, TNF-alpha, EGFR levels were measured. Statistical analyses were carried out using the NCSS (Number Cruncher Statistical System) 2007 and the PASS (Power Analysis and Sample Size) 2008 Statistical Software (UT, USA).
When the patients with metabolic syndrome were analyzed by gender, no statistically significant difference was found between the EGFR and TNF-alpha levels (p>0.05). On the other side, the visceral fat rating and GGT levels of women were significantly lower than those of men (p<0.05). However, the resistin and leptin levels were found significantly higher in female patients as compared to male patients (p<0.05).
In the present study, we did not observe any statistically significant change in abdominal adipose tissue thickness, serum TNF-alpha, adiponectin, resistin, and EGFR levels of the patients according to the number of diagnostic criteria; however, there was significant change in the patients' leptin levels.
心血管疾病是发达国家发病和死亡的主要原因之一。代谢综合征是一种常见的临床症状，在心血管疾病中具有重大风险。本研究调查了代谢综合征患者的诊断标准数量与血清脂联素、瘦素、抵抗素、肿瘤坏死因子-α、表皮生长因子受体（EGFR）水平以及腹部脂肪组织之间的相关性。
本研究共纳入了2011年3月至2011年8月期间到于姆拉尼耶培训与研究医院内科门诊就诊的40例代谢综合征患者（18例男性和22例女性）。记录了每位患者的年龄、性别、个人病史、家族病史、习惯、身高、体重、收缩压、舒张压、体重指数、腰围、臀围、身体成分（人体成分分析仪测量）等数据。采集血样进行生化检查。测定血清脂联素、瘦素、抵抗素、肿瘤坏死因子-α、EGFR水平。使用NCSS（统计分析系统）2007和PASS（功效分析与样本量）2008统计软件（美国犹他州）进行统计分析。
按性别对代谢综合征患者进行分析时，EGFR和肿瘤坏死因子-α水平之间未发现统计学显著差异（p>0.05）。另一方面，女性的内脏脂肪评级和γ-谷氨酰转移酶（GGT）水平显著低于男性（p<0.05）。然而，与男性患者相比，女性患者的抵抗素和瘦素水平显著更高（p<0.05）。
在本研究中，根据诊断标准数量，我们未观察到患者腹部脂肪组织厚度、血清肿瘤坏死因子-α、脂联素、抵抗素和EGFR水平有任何统计学显著变化；然而，患者的瘦素水平有显著变化。
