Gulen Bedia, Serinken Mustafa, Eken Cenker, Karcıoglu Özgür, Kucukdagli Okkes Taha, Kilic Elif, Akpinar Guleser, Nogay Suleyman, Kuh Mahmut
Department of Emergency Medicine, Bezmialem Vakif University, Istanbul, Turkey.
Department of Emergency Medicine, Pamukkale University, Denizli, Turkey.
Acad Emerg Med. 2016 Jul;23(7):786-9. doi: 10.1111/acem.12973. Epub 2016 Jun 16.
Burnout syndrome is recognized as a major global problem among emergency healthcare workers as it causes prevalent fatigue, job separations, and disappointment. The objective of this study was to investigate the relationship of the glial marker S100B in sera of emergency physicians with burnout syndrome and depression.
This was a prospective observational study of emergency medicine residents in three distinct university-based departments of emergency medicine. S100B levels were measured before and after the shifts. In addition, the resident completed the Maslach Burnout Inventory (MBI) and the Beck Depression Inventory (BDI) prior to starting the shift. S100B levels were compared to the occurrence of burnout syndrome and depression as measured by the MBI and BDI.
Forty-eight of 53 emergency medicine residents actively working in the three university-based EDs participated in the study. The majority of the sample had BDI scores compatible with severe depression (n = 37, 77.1%). The median scores of MBI for emotional exhaustion, depersonalization, and personal accomplishment were 29 (interquartile range [IQR] = 25 to 33), 14 (IQR = 12 to 18), and 26.5 (IQR = 22 to 31), respectively. S100B levels were found to correlate best with scores of BDI and emotional exhaustion in burnout syndrome. The difference between median S100B levels recorded in the residents with severe depression and moderate depression was found statistically significant (median [IQR] = 150 [145 to 151] vs. 135 [128 to 140]; p = 0.0005). This is also true for S100B levels detected before and after night shifts (median [IQR] = 146 [136.5 to 153.2] and 149.5 [139-158], respectively; difference = 3, 95% confidence interval = 2 to 4 [p = 0.001]).
S100B levels correlate with depression scores and emotional exhaustion in burnout syndrome. The findings suggest that S100B can be used as a marker to screen emergency medicine residents and detect individuals with high risk for depression and burnout syndrome.
职业倦怠综合征被认为是全球急诊医护人员面临的一个主要问题，因为它会导致普遍的疲劳、离职和失望情绪。本研究的目的是调查急诊医生血清中神经胶质标志物S100B与职业倦怠综合征和抑郁症之间的关系。
这是一项对三个不同的大学急诊医学系的急诊医学住院医师进行的前瞻性观察研究。在轮班前后测量S100B水平。此外，住院医师在轮班开始前完成了马氏职业倦怠量表（MBI）和贝克抑郁量表（BDI）。将S100B水平与通过MBI和BDI测量的职业倦怠综合征和抑郁症的发生率进行比较。
在三个大学急诊科积极工作的53名急诊医学住院医师中有48人参与了该研究。大多数样本的BDI得分与重度抑郁症相符（n = 37，77.1%）。MBI中情感耗竭、去个性化和个人成就感的中位数得分分别为29（四分位间距[IQR]=25至33）、14（IQR = 12至18）和26.5（IQR = 22至31）。发现S100B水平与BDI得分和职业倦怠综合征中的情感耗竭得分相关性最佳。重度抑郁症住院医师和中度抑郁症住院医师记录的S100B水平中位数差异具有统计学意义（中位数[IQR]=150[145至151]对135[128至140]；p = 0.0005）。夜班前后检测到的S100B水平也是如此（中位数[IQR]分别为146[136.5至153.2]和149.5[139 - 158]；差异 = 3，95%置信区间 = 2至4[p = 0.001]）。
S100B水平与职业倦怠综合征中的抑郁得分和情感耗竭相关。研究结果表明，S100B可作为一种标志物，用于筛查急诊医学住院医师，并检测出有抑郁症和职业倦怠综合征高风险的个体。
