Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, NHC Key Laboratory of Chronobiology, Sichuan University, Chengdu 610041, China.
Biomolecules. 2022 Aug 21;12(8):1158. doi: 10.3390/biom12081158.
Glial cells are the most abundant and widely distributed cells that maintain cerebral homeostasis in the central nervous system. They mainly include microglia, astrocytes, and the oligodendrocyte lineage cells. Moreover, glial cells may induce pathological changes, such as inflammatory responses, demyelination, and disruption of the blood-brain barrier, to regulate the occurrence and development of neurological diseases through various molecular mechanisms. Furthermore, RNA m6A modifications are involved in various pathological processes associated with glial cells. In this review, the roles of glial cells in physiological and pathological states, as well as advances in understanding the mechanisms by which glial cells regulate neurological diseases under RNA m6A modification, are summarized, hoping to provide new perspectives on the deeper mechanisms and potential therapeutic targets for neurological diseases.
胶质细胞是中枢神经系统中维持脑内环境稳态的最丰富和广泛分布的细胞。它们主要包括小胶质细胞、星形胶质细胞和少突胶质细胞谱系细胞。此外，胶质细胞可能通过各种分子机制诱导病理变化，如炎症反应、脱髓鞘和血脑屏障破坏，从而调节神经退行性疾病的发生和发展。此外，RNA m6A 修饰参与与胶质细胞相关的各种病理过程。在这篇综述中，总结了胶质细胞在生理和病理状态下的作用，以及在 RNA m6A 修饰下理解胶质细胞调节神经退行性疾病机制的进展，希望为神经退行性疾病的更深层次机制和潜在治疗靶点提供新的视角。
