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Effects of the Treg/Th17 cell balance and their associated cytokines in patients with hepatitis B infection.乙肝感染患者中调节性T细胞/辅助性T细胞17平衡及其相关细胞因子的作用。
Exp Ther Med. 2015 Feb;9(2):573-578. doi: 10.3892/etm.2014.2104. Epub 2014 Dec 3.
2
Impact of IL-22 gene polymorphism on human immunodeficiency virus infection in Han Chinese patients.白细胞介素-22 基因多态性对汉族人类免疫缺陷病毒感染者的影响。
J Microbiol Immunol Infect. 2016 Dec;49(6):872-878. doi: 10.1016/j.jmii.2014.09.002. Epub 2014 Nov 11.
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Interleukin-17A and interleukin-17F gene polymorphisms and hepatitis B virus-related hepatocellular carcinoma risk in a Chinese population.白细胞介素-17A和白细胞介素-17F基因多态性与中国人群乙型肝炎病毒相关肝细胞癌风险
Med Oncol. 2015 Jan;32(1):355. doi: 10.1007/s12032-014-0355-3. Epub 2014 Nov 28.
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Hepatitis B vaccine by intradermal route in non responder patients: an update.非应答患者皮内注射乙肝疫苗：最新进展
World J Gastroenterol. 2014 Aug 14;20(30):10383-94. doi: 10.3748/wjg.v20.i30.10383.
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Genetic polymorphisms of CXCR5 and CXCL13 are associated with non-responsiveness to the hepatitis B vaccine.CXCR5和CXCL13的基因多态性与对乙肝疫苗无反应性相关。
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Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment.白细胞介素-22 通过促进辅助性 T 细胞 17 细胞募集在乙型肝炎病毒感染的慢性肝脏炎症和纤维化中的病理作用。
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Pivotal roles of T-helper 17-related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases.辅助性T细胞17相关细胞因子白细胞介素-17、白细胞介素-22和白细胞介素-23在炎症性疾病中的关键作用。
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医护人员中乙肝疫苗无应答者和低应答者的白细胞介素-17及白细胞介素-22基因多态性

IL-17 and IL-22 genetic polymorphisms in HBV vaccine non- and low-responders among healthcare workers.

作者信息

Borzooy Zohreh, Streinu-Cercel Adrian, Mirshafiey Abbass, Khamseh Azam, Mahmoudie Masoud Karkhaneh, Navabi Shadi Sadat, Nosrati Marjan, Najafi Zahra, Hosseini Mostafa, Jazayeri Seyed Mohammad

机构信息

PhD student, Department of Infectious Diseases, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Department of Immunology and Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

MD, PhD, Department of Infectious Diseases, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; National Institute of Infectious Diseases, "Prof. Dr. Matei Balş", Bucharest, Romania.

出版信息

Germs. 2016 Mar 1;6(1):14-20. doi: 10.11599/germs.2016.1084. eCollection 2016 Mar.

DOI:10.11599/germs.2016.1084
PMID:27019828
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4788777/
Abstract

BACKGROUND

Healthcare workers constitute a population at high risk for HBV infection. Efficient vaccination options are available; however, the individual response to HBV vaccination may vary widely between subjects, potentially due to cytokine profiles and genetic variations. In the present study, we investigated the relationship between IL-17 and IL-22 gene polymorphisms versus non- and low-responsiveness to HBV vaccination in healthcare workers.

METHODS

We selected the following IL-17 and IL-22 polymorphisms: rs4711998 (A/G) from IL-17 and rs2227501 (A/T), rs2227503 (A/G), rs1026786 (A/G) from IL-22 sequences genes. These were determined by polymerase chain reaction restriction fragment length polymorphisms.

RESULTS

The IL-17 rs4711998 GG genotype had a significantly lower frequency in non-responders compared to low-responders (p=0.025). However, we did not identify a relationship between IL-22 rs1026780, rs2227501 and rs2227503 genotypes and the anti-HBs response following HBV vaccination.

CONCLUSION

These data suggest that genetic variation in rs4711998 polymorphisms in the IL-17 cytokine may influence vaccine-induced immune responses to HBV vaccine in healthcare workers.

摘要

背景

医护人员是感染乙肝病毒（HBV）的高危人群。目前有有效的疫苗接种方案；然而，个体对HBV疫苗接种的反应在受试者之间可能差异很大，这可能是由于细胞因子谱和基因变异所致。在本研究中，我们调查了医护人员中白细胞介素-17（IL-17）和白细胞介素-22（IL-22）基因多态性与对HBV疫苗接种无反应和低反应之间的关系。

方法

我们选择了以下IL-17和IL-22多态性：IL-17的rs4711998（A/G）以及IL-22序列基因的rs2227501（A/T）、rs2227503（A/G）、rs1026786（A/G）。这些通过聚合酶链反应-限制性片段长度多态性来确定。

结果

与低反应者相比，无反应者中IL-17 rs4711998 GG基因型的频率显著更低（p = 0.025）。然而，我们未发现IL-22 rs1026780、rs2227501和rs2227503基因型与HBV疫苗接种后的抗-HBs反应之间存在关联。

结论

这些数据表明，IL-17细胞因子中rs4711998多态性的基因变异可能影响医护人员对HBV疫苗的疫苗诱导免疫反应。