Department of Hepatology, Federal University of Bahia, Bahia, Brazil.
Clinical and Toxicological Analysis, Federal University of Bahia, Bahia, Brazil.
J Med Virol. 2016 Nov;88(11):1967-72. doi: 10.1002/jmv.24538. Epub 2016 Apr 22.
Hepatitis C virus (HCV) and human T-lymphotropic virus type 1 (HTLV-1) coinfection occurs in many regions. However, few studies have focused on the natural history of HCV-induced liver disease in coinfected patients. To describe the clinical, epidemiological, and histopathological aspects of HTLV-1/HCV coinfection in Brazil. A cross-sectional study with 23 patients coinfected with HCV/HTLV. The control groups consisted of 21 patients monoinfected with HCV and 20 patients monoinfected with HTLV-1. The cytokine profiles (Th1 and Th2 cell responses), clinical, laboratory features, and histopathological aspects were examined. The control group for cytokine analysis validation consisted of patients monoinfected with HTLV, and a fourth group consisted of healthy blood donors. No anthropometric differences present between the three infected groups. We observed higher serum concentrations of IFN-γ in patients coinfected with HCV/HTLV-1 than those in HCV monoinfected patients. The HCV/HTLV-1 coinfected group also exhibited a higher degree of liver steatosis than the HCV monoinfected patients. Results suggest that HCV/HTLV-1 coinfection may result in a different pattern of HCV infection due to the immunologic disorders likely associated with HTLV-1, but there is no clear evidence of the HTLV role in the natural history of HCV infection. J. Med. Virol. 88:1967-1972, 2016. © 2016 Wiley Periodicals, Inc.
丙型肝炎病毒（HCV）和人类嗜 T 淋巴细胞病毒 1 型（HTLV-1）合并感染发生在许多地区。然而，很少有研究关注合并感染患者 HCV 诱导的肝病的自然史。为了描述巴西 HCV/HTLV-1 合并感染的临床、流行病学和组织病理学特征。一项横断面研究，共纳入 23 例 HCV/HTLV 合并感染患者。对照组包括 21 例 HCV 单感染患者和 20 例 HTLV-1 单感染患者。检查了细胞因子谱（Th1 和 Th2 细胞反应）、临床、实验室特征和组织病理学方面。细胞因子分析验证的对照组包括 HTLV 单感染患者，第四组包括健康献血者。三个感染组之间没有明显的人体测量差异。我们观察到 HCV/HTLV-1 合并感染患者的血清 IFN-γ 浓度高于 HCV 单感染患者。HCV/HTLV-1 合并感染组的肝脏脂肪变性程度也高于 HCV 单感染患者。结果表明，由于可能与 HTLV-1 相关的免疫紊乱，HCV/HTLV-1 合并感染可能导致 HCV 感染的模式不同，但没有明确证据表明 HTLV 在 HCV 感染的自然史中发挥作用。J. Med. Virol. 88:1967-1972, 2016. © 2016 Wiley Periodicals, Inc.
