Lee Jae Hee, Paek Se Hee, Shin Hye Won, Lee Seung Yeon, Moon Byoung Seok, Park Jung Eun, Lim Gyeong Dong, Kim Chang Yul, Heo Yong
Department of Occupational Health, Catholic University of Daegu, Gyeongsan 38430, Korea.
Foods Research Institute, CJ CheilJedang Corp., Suwon 16495, Korea.
J Vet Sci. 2017 Mar 30;18(1):25-32. doi: 10.4142/jvs.2017.18.1.25.
Various functional activities have been reported for the fermented soybean products (DJ) and (CGJ), although no systemic investigations of their immune functions have been conducted to date. We examined the effects of an experimental diet of DJ, CGJ, or a mixture of unfermented raw material for 4 weeks on overall immunity and immune safety in mice. No significant alterations were observed in peripheral or splenic immune cells among groups. Enhanced splenic natural killer cell activity was observed in the DJ and CGJ groups compared with the plain diet group. T helper type-1 (Th1)-mediated immune responses were enhanced in the DJ and CGJ groups with an upregulated production ratio of IFN-γ . IL-4 and IgG2a . IgG1 in stimulated splenic T and B cells, respectively. Resistance to infection was observed in the DJ and CGJ groups. Overall, the results of this study suggest that DJ and CGJ intake consolidates humoral and cellular immunity to Th1 responses.
尽管迄今为止尚未对发酵大豆制品（DJ）和（CGJ）的免疫功能进行系统研究，但已有关于它们各种功能活性的报道。我们研究了给小鼠喂食DJ、CGJ或未发酵原料混合物的实验性饮食4周对整体免疫和免疫安全性的影响。各组外周或脾脏免疫细胞未观察到显著变化。与普通饮食组相比，DJ组和CGJ组脾脏自然杀伤细胞活性增强。DJ组和CGJ组中，辅助性T细胞1型（Th1）介导的免疫反应增强，刺激的脾脏T细胞和B细胞中IFN-γ、IL-4和IgG2a、IgG1的产生比例分别上调。DJ组和CGJ组观察到对感染的抵抗力。总体而言，本研究结果表明，摄入DJ和CGJ可增强体液免疫和细胞免疫对Th1反应的作用。
