Govus A D, Peeling P, Abbiss C R, Lawler N G, Swinkels D W, Laarakkers C M, Thompson K G, Peiffer J J, Gore C J, Garvican-Lewis L A
Institute for Sport & Physical Activity Research, University of Bedfordshire, Bedford, UK.
School of Sport Science, Exercise & Health, University of Western Australia, Crawley, Western Australia, Australia.
Scand J Med Sci Sports. 2017 Jul;27(7):704-713. doi: 10.1111/sms.12685. Epub 2016 Mar 31.
The post-exercise hepcidin response during prolonged (>2 weeks) hypoxic exposure is not well understood. We compared plasma hepcidin levels 3 h after exercise [6 × 1000 m at 90% of maximal aerobic running velocity (vVO )] performed in normoxia and normobaric hypoxia (3000 m simulate altitude) 1 week before, and during 14 days of normobaric hypoxia [196.2 ± 25.6 h (median: 200.8 h; range: 154.3-234.8 h) at 3000 m simulated altitude] in 10 well-trained distance runners (six males, four females). Venous blood was also analyzed for hepcidin after 2 days of normobaric hypoxia. Hemoglobin mass (Hb ) was measured via CO rebreathing 1 week before and after 14 days of hypoxia. Hepcidin was suppressed after 2 (Cohen's d = -2.3, 95% confidence interval: [-2.9, -1.6]) and 14 days of normobaric hypoxia (d = -1.6 [-2.6, -0.6]). Hepcidin increased from baseline, 3 h post-exercise in normoxia (d = 0.8 [0.2, 1.3]) and hypoxia (d = 0.6 [0.3, 1.0]), both before and after exposure (normoxia: d = 0.7 [0.3, 1.2]; hypoxia: d = 1.3 [0.4, 2.3]). In conclusion, 2 weeks of normobaric hypoxia suppressed resting hepcidin levels, but did not alter the post-exercise response in either normoxia or hypoxia, compared with the pre-exposure response.
长时间（>2周）低氧暴露期间运动后铁调素的反应尚未得到充分了解。我们比较了10名训练有素的长跑运动员（6名男性，4名女性）在常氧和常压低氧（模拟海拔3000米）环境下，于低氧暴露前1周、低氧暴露14天期间（模拟海拔3000米，时长196.2±25.6小时（中位数：200.8小时；范围：154.3 - 234.8小时））进行运动（以最大有氧跑步速度（vVO）的90%进行6×1000米跑）后3小时的血浆铁调素水平。在常压低氧2天后也对静脉血进行了铁调素分析。通过一氧化碳再呼吸法在低氧暴露14天前后1周测量血红蛋白量（Hb）。常压低氧2天（Cohen's d = -2.3，95%置信区间：[-2.9, -1.6]）和14天（d = -1.6 [-2.6, -0.6]）后铁调素受到抑制。在常氧（d = 0.8 [0.2, 1.3]）和低氧（d = 0.6 [0.3, 1.0]）环境下，运动后3小时铁调素均从基线水平升高，在暴露前和暴露后均如此（常氧：d = 0.7 [0.3, 1.2]；低氧：d = 1.3 [0.4, 2.3]）。总之，与暴露前反应相比，2周的常压低氧抑制了静息铁调素水平，但未改变常氧或低氧环境下运动后的反应。
