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Hypothyroidism and carpal tunnel syndrome: a meta-analysis.甲状腺功能减退症与腕管综合征：一项荟萃分析。
Muscle Nerve. 2014 Dec;50(6):879-83. doi: 10.1002/mus.24453. Epub 2014 Oct 30.
2
Neuromuscular status of thyroid diseases: a prospective clinical and electrodiagnostic study.甲状腺疾病的神经肌肉状态：一项前瞻性临床与电诊断研究。
Electromyogr Clin Neurophysiol. 2007 Mar-Apr;47(2):67-78.
3
The relationship of obesity, age, and carpal tunnel syndrome: more complex than was thought?肥胖、年龄与腕管综合征之间的关系：比想象中更复杂？
Muscle Nerve. 2005 Oct;32(4):527-32. doi: 10.1002/mus.20408.
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Risk factors in carpal tunnel syndrome.腕管综合征的危险因素。
J Hand Surg Br. 2004 Aug;29(4):315-20. doi: 10.1016/j.jhsb.2004.02.009.
5
Indications for requesting laboratory tests for concurrent diseases in patients with carpal tunnel syndrome: a systematic review.腕管综合征患者并发疾病实验室检查申请的指征：一项系统评价
Clin Chem. 2003 Sep;49(9):1437-44. doi: 10.1373/49.9.1437.
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An evaluation of gender, obesity, age and diabetes mellitus as risk factors for carpal tunnel syndrome.对性别、肥胖、年龄和糖尿病作为腕管综合征危险因素的评估。
Clin Neurophysiol. 2002 Sep;113(9):1429-34. doi: 10.1016/s1388-2457(02)00201-8.
7
Prevalence of smoking, obesity, diabetes mellitus, and thyroid disease in patients with carpal tunnel syndrome.腕管综合征患者中吸烟、肥胖、糖尿病和甲状腺疾病的患病率。
Ann Plast Surg. 2002 Mar;48(3):269-73. doi: 10.1097/00000637-200203000-00007.
8
The effects of hypothyroidism and thyroid replacement on the development of carpal tunnel syndrome.甲状腺功能减退及甲状腺替代治疗对腕管综合征发展的影响。
J Hand Surg Am. 2000 Jul;25(4):734-9. doi: 10.1053/jhsu.2000.8642.
9
Carpal tunnel syndrome: a nested case-control study of risk factors in women.腕管综合征：一项关于女性危险因素的巢式病例对照研究。
Am J Epidemiol. 2000 Mar 15;151(6):566-74. doi: 10.1093/oxfordjournals.aje.a010244.
10
Pathophysiology of nerve compression syndromes: response of peripheral nerves to loading.神经压迫综合征的病理生理学：周围神经对负荷的反应。
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甲状腺功能减退症中的腕管综合征

Carpal Tunnel Syndrome in Hypothyroidism.

作者信息

Karne Sampada Swapneel, Bhalerao Nilima Sudhakar

机构信息

Professor, Department of Medicine, SKN Medical College , Pune, Maharashtra, India .

Assistant Professor, Department of Medicine, SKN Medical College , Pune, Maharashtra, India .

出版信息

J Clin Diagn Res. 2016 Feb;10(2):OC36-8. doi: 10.7860/JCDR/2016/16464.7316. Epub 2016 Feb 1.

DOI:10.7860/JCDR/2016/16464.7316
PMID:27042500
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4800566/
Abstract

INTRODUCTION

Carpal Tunnel Syndrome (CTS) is an entrapment neuropathy that occurs due to compression of median nerve in the carpal tunnel and hypothyroidism is one of the important causes of CTS.

AIM

To study clinical profile of carpal tunnel syndrome in patients with primary hypothyroidism.

MATERIALS AND METHODS

This was cross-sectional study done in Smt. Kashibai Navale Medical College, Pune, Maharashtra. Adult patients with diagnosis of primary hypothyroidism were included in this study. Patients with other possible causes of CTS were excluded. Detailed medical history was obtained and all patients underwent clinical examination and nerve conduction study by electrophysiological method.

RESULTS

Total 36 adult patients were included in this study, 86.1% females and 13.9% males. CTS were found in 6 (16.7%) patients. Increased Body Mass Index (BMI) and presence of clinical symptoms and/or signs of CTS correlated independently with presence of CTS in hypothyroidism. (p-value- 0.03 and < 0.0001 respectively). No correlation was found between gender, age of the patient, duration of disease, serum TSH level, aetiology of the disease, thyroid hormone replacement therapy and occurrence of CTS in hypothyroidism.

CONCLUSION

Increase in BMI is an important risk factor for CTS in hypothyroidism and clinical evidence of CTS is a very sensitive parameter for the same.

摘要

引言

腕管综合征（CTS）是一种因正中神经在腕管内受压而导致的卡压性神经病变，甲状腺功能减退是导致CTS的重要原因之一。

目的

研究原发性甲状腺功能减退患者腕管综合征的临床特征。

材料与方法

这是一项在马哈拉施特拉邦浦那市什姆特·卡希拜·纳瓦尔医学院开展的横断面研究。本研究纳入了诊断为原发性甲状腺功能减退的成年患者。排除了其他可能导致CTS的病因。获取了详细的病史，所有患者均接受了临床检查和通过电生理方法进行的神经传导研究。

结果

本研究共纳入36例成年患者，其中女性占86.1%，男性占l3.9%。6例（16.7%）患者发现患有CTS。体重指数（BMI）升高以及存在CTS的临床症状和/或体征与甲状腺功能减退患者中CTS的存在独立相关。（p值分别为0.03和<0.0001）。在甲状腺功能减退患者中，未发现性别、患者年龄、病程、血清促甲状腺激素水平、疾病病因、甲状腺激素替代治疗与CTS的发生之间存在相关性。

结论

BMI升高是甲状腺功能减退患者发生CTS的重要危险因素，CTS的临床证据是其非常敏感的参数。