Department of Chemistry, East Carolina University Greenville, North Carolina 27858, United States.
Department of Chemistry, University of Connecticut , Storrs, Connecticut 06269, United States.
Anal Chem. 2016 May 3;88(9):4584-99. doi: 10.1021/acs.analchem.5b04772. Epub 2016 Apr 14.
Routine in vitro bioassays and animal toxicity studies of drug and environmental chemical candidates fail to reveal toxicity in ∼30% of cases. This Feature article addresses research on new approaches to in vitro toxicity testing as well as our own efforts to produce high-throughput genotoxicity arrays and LC-MS/MS approaches to reveal possible chemical pathways of toxicity.
在药物和环境化学候选物的常规体外生物测定和动物毒性研究中，约有 30%的情况未能揭示其毒性。本文介绍了新的体外毒性测试方法的研究，以及我们自己在生产高通量遗传毒性阵列和 LC-MS/MS 方法以揭示可能的毒性化学途径方面的努力。
