Regnault Clément, Dheeman Dharmendra S, Hochstetter Axel
Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.
Division of Biomedical Engineering, School of Engineering, University of Glasgow, Glasgow G12 8LT, UK.
High Throughput. 2018 Jun 20;7(2):18. doi: 10.3390/ht7020018.
In this review, we give an overview of the current state of microfluidic-based high-throughput drug assays. In this highly interdisciplinary research field, various approaches have been applied to high-throughput drug screening, including microtiter plate, droplets microfluidics as well as continuous flow, diffusion and concentration gradients-based microfluidic drug assays. Therefore, we reviewed over 100 recent publications in the field and sorted them according to their approach. As a result, we are showcasing, comparing and discussing broadly applied approaches as well as singular promising ones that might contribute to shaping the future of this field.
在本综述中，我们概述了基于微流体的高通量药物分析的当前状态。在这个高度跨学科的研究领域中，各种方法已被应用于高通量药物筛选，包括微量滴定板、液滴微流体以及基于连续流动、扩散和浓度梯度的微流体药物分析。因此，我们回顾了该领域最近的100多篇出版物，并根据其方法进行了分类。结果，我们展示、比较并讨论了广泛应用的方法以及可能有助于塑造该领域未来的独特且有前景的方法。
