运动强度和营养建议对肥胖儿童及青少年心肌功能的影响：一项多中心随机对照试验研究方案
Effects of exercise intensity and nutrition advice on myocardial function in obese children and adolescents: a multicentre randomised controlled trial study protocol.
作者信息
Dias Katrin A, Coombes Jeff S, Green Daniel J, Gomersall Sjaan R, Keating Shelley E, Tjonna Arnt Erik, Hollekim-Strand Siri Marte, Hosseini Mansoureh Sadat, Ro Torstein Baade, Haram Margrete, Huuse Else Marie, Davies Peter S W, Cain Peter A, Leong Gary M, Ingul Charlotte B
机构信息
School of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, Brisbane, Queensland, Australia.
School of Sport Science, Exercise and Health, The University of Western Australia, Perth, Western Australia, Australia Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
出版信息
BMJ Open. 2016 Apr 4;6(4):e010929. doi: 10.1136/bmjopen-2015-010929.
INTRODUCTION
The prevalence of paediatric obesity is increasing, and with it, lifestyle-related diseases in children and adolescents. High-intensity interval training (HIIT) has recently been explored as an alternate to traditional moderate-intensity continuous training (MICT) in adults with chronic disease and has been shown to induce a rapid reversal of subclinical disease markers in obese children and adolescents. The primary aim of this study is to compare the effects of HIIT with MICT on myocardial function in obese children and adolescents.
METHODS AND ANALYSIS
Multicentre randomised controlled trial of 100 obese children and adolescents in the cities of Trondheim (Norway) and Brisbane (Australia). The trial will examine the efficacy of HIIT to improve cardiometabolic outcomes in obese children and adolescents. Participants will be randomised to (1) HIIT and nutrition advice, (2) MICT and nutrition advice or (3) nutrition advice. Participants will partake in supervised exercise training and/or nutrition sessions for 3 months. Measurements for study end points will occur at baseline, 3 months (postintervention) and 12 months (follow-up). The primary end point is myocardial function (peak systolic tissue velocity). Secondary end points include vascular function (flow-mediated dilation assessment), quantity of visceral and subcutaneous adipose tissue, myocardial structure and function, body composition, cardiorespiratory fitness, autonomic function, blood biochemistry, physical activity and nutrition. Lean, healthy children and adolescents will complete measurements for all study end points at one time point for comparative cross-sectional analyses.
ETHICS AND DISSEMINATION
This randomised controlled trial will generate substantial information regarding the effects of exercise intensity on paediatric obesity, specifically the cardiometabolic health of this at-risk population. It is expected that communication of results will allow for the development of more effective evidence-based exercise prescription guidelines in this population while investigating the benefits of HIIT on subclinical markers of disease.
TRIAL REGISTRATION NUMBER
NCT01991106.
引言
儿童肥胖的患病率正在上升，随之而来的是儿童和青少年中与生活方式相关的疾病。高强度间歇训练（HIIT）最近已被探索作为患有慢性病的成年人传统中等强度持续训练（MICT）的替代方法，并且已被证明可使肥胖儿童和青少年的亚临床疾病标志物迅速逆转。本研究的主要目的是比较HIIT与MICT对肥胖儿童和青少年心肌功能的影响。
方法与分析
在挪威特隆赫姆市和澳大利亚布里斯班市对100名肥胖儿童和青少年进行多中心随机对照试验。该试验将研究HIIT改善肥胖儿童和青少年心脏代谢结局的疗效。参与者将被随机分为（1）HIIT和营养建议组，（2）MICT和营养建议组或（3）营养建议组。参与者将参加为期3个月的监督运动训练和/或营养课程。研究终点的测量将在基线、3个月（干预后）和12个月（随访）时进行。主要终点是心肌功能（峰值收缩期组织速度）。次要终点包括血管功能（血流介导的扩张评估）、内脏和皮下脂肪组织的量、心肌结构和功能、身体成分、心肺适能、自主神经功能、血液生化、身体活动和营养。体型瘦且健康的儿童和青少年将在一个时间点完成所有研究终点的测量，用于比较性横断面分析。
伦理与传播
这项随机对照试验将产生大量关于运动强度对儿童肥胖影响的信息，特别是对这一高危人群心脏代谢健康的影响。预计结果的交流将有助于制定针对该人群更有效的循证运动处方指南，同时研究HIIT对疾病亚临床标志物的益处。
试验注册号
NCT01991106。
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