Centre ofMolecular Inflammation Research, Department of Cancer Research and Molecular Medicine; Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust; Mid-Norway Sepsis Research Center, Norwegian University of Science and Technology, Trondheim.
Departments ofCirculation and Medical Imaging; Mid-Norway Sepsis Research Center, Norwegian University of Science and Technology, Trondheim; Clinic of Anaesthesia and Intensive Care.
Open Forum Infect Dis. 2016 Mar 1;3(2):ofw048. doi: 10.1093/ofid/ofw048. eCollection 2016 Mar.
Staphylococcus aureus is a common cause of severe bloodstream infection. We performed a systematic review to assess whether consultation with infectious disease specialists decreased all-cause mortality or rate of complications of S aureus bloodstream infections. The review also assessed parameters associated with the quality of management of the infection. We searched for eligible studies in PubMed, Embase, Scopus, and clinical trials.gov as well as the references of included studies. We identified 22 observational studies and 1 study protocol for a randomized trial. A meta-analysis was not performed because of the high risk of bias in the included studies. The outcomes are reported in a narrative review. Most included studies reported survival benefit, in the adjusted analysis. Recommended management strategies were carried out significantly more often among patients seen by an infectious disease specialist. Trials, such as cluster-randomized controlled trials, can more validly assess the studies at low risk of bias.
金黄色葡萄球菌是严重血流感染的常见病因。我们进行了系统评价，以评估咨询传染病专家是否降低金黄色葡萄球菌血流感染的全因死亡率或并发症发生率。该评价还评估了与感染管理质量相关的参数。我们在 PubMed、Embase、Scopus 和 clinicaltrials.gov 以及纳入研究的参考文献中搜索了合格的研究。我们确定了 22 项观察性研究和 1 项随机试验的研究方案。由于纳入研究的偏倚风险很高，因此未进行荟萃分析。结果以叙述性综述的形式报告。大多数纳入的研究报告了调整分析后的生存获益。在传染病专家就诊的患者中，推荐的治疗策略的实施频率显著更高。例如，整群随机对照试验等试验可以更有效地评估低偏倚风险的研究。
