Johnson Derek C, Lhaki Pema, Bhatta Madhav P, Kempf Mirjam-Colette, Smith Jennifer S, Bhattarai Pankaj, Aryal Shilu, Chamot Eric, Regmi Kiran, Vermund Sten H, Shrestha Sadeep
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
NFCC/NFCC International, Kathmandu, Nepal.
Int Health. 2016 Jul;8(4):261-8. doi: 10.1093/inthealth/ihw015. Epub 2016 Apr 4.
In April 2014 we investigated the association of migration of a woman's husband with her high-risk human papillomavirus (HR-HPV) infection status and her abnormal cervical cytology status in the Achham district of rural Far-Western Nepal.
Women were surveyed and screened for HR-HPV during a health camp conducted by the Nepal Fertility Care Center. Univariate and multivariable statistical tests were performed to determine the association of a husband's migration status with HR-HPV infection and cervical cytology status.
In 265 women, the prevalence of HR-HPV was 7.5% (20/265), while the prevalence of abnormal cervical cytology, defined using the Bethesda system as atypical glandular cells of undetermined significance or worse, was 7.6% (19/251). Half of the study participants (50.8%, 130/256) had husbands who had reported migrating for work at least once. Women aged ≤34 years were significantly less likely to test positive for HR-HPV than women aged >34 years (OR 0.22, 95% CI 0.07 to 0.71). HR-HPV infection and abnormal cervical cytology status were not directly associated with a husband's migration.
Older women were found to have a higher prevalence of HPV than younger women. It is possible that a husband's migration for work could be delaying HR-HPV infections in married women until an older age.
2014年4月，我们在尼泊尔远西地区阿昌农村地区调查了女性丈夫的外出务工情况与她的高危型人乳头瘤病毒（HR-HPV）感染状况及宫颈细胞学异常状况之间的关联。
在尼泊尔生育保健中心举办的一次健康营活动中，对女性进行了调查并筛查了HR-HPV。进行单变量和多变量统计检验，以确定丈夫的外出务工状况与HR-HPV感染及宫颈细胞学状况之间的关联。
在265名女性中，HR-HPV的患病率为7.5%（20/265），而按照贝塞斯达系统定义为意义不明确的非典型腺细胞或更严重情况的宫颈细胞学异常患病率为7.6%（19/251）。一半的研究参与者（50.8%，130/256）的丈夫报告至少有一次外出务工。年龄≤34岁的女性HR-HPV检测呈阳性的可能性显著低于年龄>34岁的女性（比值比0.22，95%置信区间0.07至0.71）。HR-HPV感染和宫颈细胞学异常状况与丈夫的外出务工没有直接关联。
发现老年女性的HPV患病率高于年轻女性。丈夫外出务工可能会使已婚女性的HR-HPV感染推迟到年龄更大的时候。
