Loyola Rodriguez J P, Galvan Torres L J, Martinez Martinez R E, Abud Mendoza C, Medina Solis C E, Ramos Coronel S, Garcia Cortes J O, Domínguez Pérez R A
Advanced Education in General Dentistry, Master Degree Program at San Luis Potosi University, Mexico
Advanced Education in General Dentistry, Master Degree Program at San Luis Potosi University, Mexico.
Lupus. 2016 Oct;25(12):1349-56. doi: 10.1177/0961203316640909. Epub 2016 Apr 5.
The objective of this study was to determine dental caries frequency and to analyze salivary and bacterial factors associated with active and inactive systemic lupus erythematous (SLE) patients. Also, a proposal to identify dental caries by a surface, teeth, and the patient was developed.
A cross-sectional, blinded study that included 60 SLE patients divided into two groups of 30 subjects each, according to the Activity Index for Diagnosis of Systemic Lupus Erythematous (SLEDAI). The decayed, missing, and filled teeth (DMFT) index and Integrative Dental Caries Index (IDCI) were used for analyzing dental caries. The saliva variables recorded were: flow, pH, and buffer capacity. The DNA copies of Streptococcus mutans and Streptococcus sobrinus were estimated by real-time PCR.
The caries frequency was 85% for SLE subjects (73.3% for inactive systemic lupus erythematous (ISLE) and 100% for active systemic lupus erythematous (ASLE)); DMFT for the SLE group was 12.6 ± 5.7 and the IDCI was (9.8 ± 5.9). The ASLE group showed a salivary flow of 0.65 compared with 0.97 ml/1 min from the ISLE group; all variables mentioned above showed a statistical difference (p < 0.05). The salivary pH was 4.6 (6.06 for ISLE and 3.9 for ASLE). The DNA copies of S. mutans and S. sobrinus were high; all variables mentioned above show a significant statistical difference (p < 0.05) between groups.
SLE patients had high DMFT and IDCI scores that were associated with a decrease in salivary flow, pH, and buffer capacity. There were high counts of S. sobrinus and S. mutans species, and IDCI is a useful tool to provide more detail about dental caries in epidemiological studies.
本研究的目的是确定龋齿发生率，并分析与活动期和非活动期系统性红斑狼疮（SLE）患者相关的唾液和细菌因素。此外，还提出了一种按表面、牙齿和患者来识别龋齿的方法。
一项横断面、双盲研究，纳入60例SLE患者，根据系统性红斑狼疮诊断活动指数（SLEDAI）分为两组，每组30名受试者。采用龋失补牙（DMFT）指数和综合龋齿指数（IDCI）分析龋齿情况。记录的唾液变量包括：流量、pH值和缓冲能力。通过实时聚合酶链反应（PCR）估计变形链球菌和远缘链球菌的DNA拷贝数。
SLE患者的龋齿发生率为85%（非活动期系统性红斑狼疮（ISLE）为73.3%，活动期系统性红斑狼疮（ASLE）为100%）；SLE组的DMFT为12.6±5.7，IDCI为（9.8±5.9）。ASLE组的唾液流量为0.65，而ISLE组为0.97毫升/1分钟；上述所有变量均显示出统计学差异（p<0.05）。唾液pH值为4.6（ISLE为6.06，ASLE为3.9）。变形链球菌和远缘链球菌的DNA拷贝数较高；上述所有变量在两组之间均显示出显著的统计学差异（p<0.05）。
SLE患者的DMFT和IDCI评分较高，这与唾液流量、pH值和缓冲能力降低有关。远缘链球菌和变形链球菌的数量较多，并且IDCI是在流行病学研究中提供更多龋齿详细信息的有用工具。
