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脊椎动物触觉感知的进化特化。

Evolutionary Specialization of Tactile Perception in Vertebrates.

机构信息

Department of Cellular & Molecular Physiology, Yale University, New Haven, Connecticut;

Department of Cellular & Molecular Physiology, Yale University, New Haven, Connecticut; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University, New Haven, Connecticut; and Department of Neuroscience, Yale University, New Haven, Connecticut

出版信息

Physiology (Bethesda). 2016 May;31(3):193-200. doi: 10.1152/physiol.00036.2015.

DOI:10.1152/physiol.00036.2015
PMID:27053733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5005274/
Abstract

Evolution has endowed vertebrates with the remarkable tactile ability to explore the world through the perception of physical force. Yet the sense of touch remains one of the least well understood senses at the cellular and molecular level. Vertebrates specializing in tactile perception can highlight general principles of mechanotransduction. Here, we review cellular and molecular adaptations that underlie the sense of touch in typical and acutely mechanosensitive vertebrates.

摘要

进化赋予了脊椎动物一种非凡的触觉能力,使它们能够通过感知物理力来探索世界。然而,在细胞和分子水平上,触觉仍然是了解最少的感觉之一。专门从事触觉感知的脊椎动物可以突出机械转导的一般原理。在这里,我们回顾了典型和急性机械敏感脊椎动物触觉的细胞和分子适应。

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本文引用的文献

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Piezo2 is the major transducer of mechanical forces for touch sensation in mice.Piezo2是小鼠触觉中机械力的主要传感器。
Nature. 2014 Dec 4;516(7529):121-5. doi: 10.1038/nature13980.
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Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing.大规模单细胞 RNA 测序对感觉神经元类型进行无偏分类。
Nat Neurosci. 2015 Jan;18(1):145-53. doi: 10.1038/nn.3881. Epub 2014 Nov 24.
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