微生物群特异性Th17细胞：炎症性肠病调节中的阴阳平衡
Microbiota-specific Th17 Cells: Yin and Yang in Regulation of Inflammatory Bowel Disease.
作者信息
Wu Wei, Chen Feidi, Liu Zhanju, Cong Yingzi
机构信息
*Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas; †Department of Gastroenterology, The Shanghai Tenth People's Hospital, Tongji University, Shanghai, China; and ‡Department of Pathology, University of Texas Medical Branch, Galveston, Texas.
出版信息
Inflamm Bowel Dis. 2016 Jun;22(6):1473-82. doi: 10.1097/MIB.0000000000000775.
Multiple mechanisms are involved in regulation of host response to microbiota to maintain the intestinal homeostasis. Th17 cells are enriched in the intestinal lamina propria under steady conditions. Many studies have demonstrated that microbiota-reactive Th17 cells in the intestines mediate the pathogenesis of inflammatory bowel diseases. However, clinical trials of anti-interleukin-17A or anti-interleukin-17RA antibodies in patients with Crohn's Disease show no improvement or even exacerbation of disease. Accumulating data has also indicated that Th17 cells may provide a protective effect as well to the intestines from inflammatory insults under homeostasis regulation, even under inflammatory conditions. Thus both proinflammatory and anti-inflammatory functions of intestinal Th17 cells have emerged under various conditions. In this review article, we will summarize recent progresses of Th17 cells in regulation of intestinal homeostasis and in the pathogenesis of inflammatory bowel diseases.
宿主对微生物群的反应调控涉及多种机制，以维持肠道内稳态。在稳态条件下，Th17细胞在肠道固有层中富集。许多研究表明，肠道中对微生物群有反应的Th17细胞介导炎症性肠病的发病机制。然而，针对克罗恩病患者的抗白细胞介素-17A或抗白细胞介素-17RA抗体的临床试验显示，疾病并无改善甚至恶化。越来越多的数据还表明，即使在炎症条件下，Th17细胞在稳态调节下也可能对肠道起到保护作用，使其免受炎症损伤。因此，在各种条件下，肠道Th17细胞的促炎和抗炎功能都已显现。在这篇综述文章中，我们将总结Th17细胞在调节肠道内稳态及炎症性肠病发病机制方面的最新进展。
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