Sood Mariam R, Sereno Martin I
Department of Psychological Sciences, Birkbeck, University of London, Malet Street, London, WC1E 7HX, United Kingdom.
Experimental Psychology, Division of Psychology and Language Sciences, 26 Bedford Way, London, WC1H 0AP, United Kingdom.
Hum Brain Mapp. 2016 Aug;37(8):2784-810. doi: 10.1002/hbm.23208. Epub 2016 Apr 7.
Cortical mapping techniques using fMRI have been instrumental in identifying the boundaries of topological (neighbor-preserving) maps in early sensory areas. The presence of topological maps beyond early sensory areas raises the possibility that they might play a significant role in other cognitive systems, and that topological mapping might help to delineate areas involved in higher cognitive processes. In this study, we combine surface-based visual, auditory, and somatomotor mapping methods with a naturalistic reading comprehension task in the same group of subjects to provide a qualitative and quantitative assessment of the cortical overlap between sensory-motor maps in all major sensory modalities, and reading processing regions. Our results suggest that cortical activation during naturalistic reading comprehension overlaps more extensively with topological sensory-motor maps than has been heretofore appreciated. Reading activation in regions adjacent to occipital lobe and inferior parietal lobe almost completely overlaps visual maps, whereas a significant portion of frontal activation for reading in dorsolateral and ventral prefrontal cortex overlaps both visual and auditory maps. Even classical language regions in superior temporal cortex are partially overlapped by topological visual and auditory maps. By contrast, the main overlap with somatomotor maps is restricted to a small region on the anterior bank of the central sulcus near the border between the face and hand representations of M-I. Hum Brain Mapp 37:2784-2810, 2016. © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
使用功能磁共振成像（fMRI）的皮质映射技术在确定早期感觉区域中拓扑（邻域保留）映射的边界方面发挥了重要作用。早期感觉区域之外存在拓扑映射，这增加了它们可能在其他认知系统中发挥重要作用的可能性，并且拓扑映射可能有助于描绘参与更高认知过程的区域。在本研究中，我们将基于表面的视觉、听觉和躯体运动映射方法与同一组受试者的自然阅读理解任务相结合，以对所有主要感觉模态的感觉运动映射与阅读处理区域之间的皮质重叠进行定性和定量评估。我们的结果表明，在自然阅读理解过程中的皮质激活与拓扑感觉运动映射的重叠比以往认识到的更为广泛。枕叶和顶下叶附近区域的阅读激活几乎完全与视觉映射重叠，而背外侧和腹侧前额叶皮质中阅读的额叶激活的很大一部分与视觉和听觉映射都重叠。甚至颞上叶皮质中的经典语言区域也部分地与拓扑视觉和听觉映射重叠。相比之下，与躯体运动映射的主要重叠仅限于中央沟前壁上靠近初级运动区（M-I）面部和手部表征边界的一个小区域。《人类脑图谱》37:2784 - 2810，2016年。© 2016作者 人类脑图谱 由威利期刊公司出版
