Nomura Daniel K, Casida John E
Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA; Department of Chemistry, University of California, Berkeley, CA 94720, USA.
Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA; Department of Environmental Science, Policy, and Management, University of California, Berkeley, CA 94720, USA.
Chem Biol Interact. 2016 Nov 25;259(Pt B):211-222. doi: 10.1016/j.cbi.2016.04.004. Epub 2016 Apr 9.
Lipids play diverse and important biological roles including maintaining cellular integrity, storing fat for energy, acting as signaling molecules, and forming microdomains to support membrane protein signaling. Altering the levels of specific lipid species through activating or inactivating their biosynthetic or degradative pathways has been shown to provide either therapeutic benefit or cause disease. This review focuses on the functional, therapeutic, and (patho)physiological roles of lipases within the serine hydrolase superfamily and their inhibitors, with particular emphasis on the pharmacological tools, drugs, and environmental chemicals that inhibit these lipases.
脂质发挥着多样且重要的生物学作用，包括维持细胞完整性、储存脂肪以供能、作为信号分子以及形成微结构域以支持膜蛋白信号传导。通过激活或失活特定脂质种类的生物合成或降解途径来改变其水平，已显示出具有治疗益处或引发疾病。本综述聚焦于丝氨酸水解酶超家族中脂肪酶及其抑制剂的功能、治疗和（病理）生理作用，尤其着重于抑制这些脂肪酶的药理学工具、药物和环境化学物质。
