Fu Jing, Zeng Cheng, Zeng Zheling, Wang Baogui, Wen Xuefang, Yu Ping, Gong Deming
State Key Laboratory of Food Science and Technology, Nanchang University, 235 Nanjing East Road, Nanchang, 330047, China.
The First Clinical School, Nanchang University, Nanchang, 330031, China.
Lipids. 2016 Jun;51(6):693-702. doi: 10.1007/s11745-016-4147-8. Epub 2016 Apr 11.
The effects of dietary Cinnamomum camphora seed kernel oil (CCSKO) containing medium-chain triacylglycerols on lipid metabolism and mRNA and protein expression of β-3 adrenergic receptor in adipose tissue were studied in diet-induced obese rats. High fat food-induced obese rats were randomly divided into CCSKO group, Lard group, Soybean oil (SOY) group and naturally restoring group (n = 10). Rats fed with low fat food were used as a normal control group. Significant decreases in body mass and abdominal fat mass/body mass after 12 weeks were found in CCSKO group as compared with Lard and SOY groups (p < 0.05). Levels of blood total cholesterol (TC), triglyceride, free fatty acid, fasting insulin and insulin resistance in the CCSKO group were decreased significantly, and noradrenaline level and insulin sensitivity index in the CCSKO group were significantly higher than other groups. Meanwhile liver TC and triglyceride levels in the CCSKO group were also decreased markedly. Expression levels of β3-adrenergic receptor mRNA and protein were higher in CCSKO group than in Lard and SOY groups. These results suggest that CCSKO may contribute to reduction of the body fat mass, promote lipid metabolism and up-regulate β3-adrenergic receptor expression in high fat diet-induced obese rats.
在饮食诱导的肥胖大鼠中，研究了含有中链甘油三酯的膳食樟籽仁油（CCSKO）对脂质代谢以及脂肪组织中β-3肾上腺素能受体mRNA和蛋白表达的影响。将高脂食物诱导的肥胖大鼠随机分为CCSKO组、猪油组、大豆油（SOY）组和自然恢复组（n = 10）。以喂食低脂食物的大鼠作为正常对照组。与猪油组和大豆油组相比，12周后CCSKO组大鼠的体重以及腹部脂肪量/体重显著降低（p < 0.05）。CCSKO组的血液总胆固醇（TC）、甘油三酯、游离脂肪酸、空腹胰岛素和胰岛素抵抗水平显著降低，且CCSKO组的去甲肾上腺素水平和胰岛素敏感指数显著高于其他组。同时，CCSKO组的肝脏TC和甘油三酯水平也明显降低。CCSKO组中β3-肾上腺素能受体mRNA和蛋白的表达水平高于猪油组和大豆油组。这些结果表明，CCSKO可能有助于降低高脂饮食诱导的肥胖大鼠的体脂量，促进脂质代谢并上调β3-肾上腺素能受体表达。
