Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain.
Gerontology. 2018;64(1):3-10. doi: 10.1159/000479065. Epub 2017 Sep 9.
The role of diet and inflammation in successful ageing is not transparent, and as such, is still being investigated. The aim of the present work was to evaluate the inflammatory potential of dietary habits in the successful ageing of a random sample of older adults living in the Mediterranean basin and who participated in the MEDIS (MEDiterranean ISlands) study.
During 2005-2016, 3,128 older adults (aged 65-100 years) from 24 Mediterranean islands and the rural Mani region (Peloponnesus) of Greece were enrolled in the study. A multidimensional successful ageing index consisting of 10 components was employed. A validated and reproducible Food Frequency Questionnaire (FFQ) was used to evaluate the dietary habits of the older adults. A nutrition anti-inflammatory (NAI) score based on the participants' specific dietary habits was assessed.
Participants with high NAI scores (proinflammatory nutrition) had a higher prevalence of hypercholesterolemia and lower levels of successful ageing. After adjusting for several confounders, the NAI score was associated with successful ageing (-0.03, 95% CI -0.5 to -0.006). Stratified analysis by gender and advanced age revealed heterogeneity in the NAI score, predicting successful ageing.
The inflammatory potential of nutrition was reported as an important factor for successful ageing, suggesting that further research is needed on the role of anti- and proinflammatory dietary habits in healthy and successful ageing.
饮食和炎症在成功老龄化中的作用尚不清楚，因此仍在研究中。本研究旨在评估饮食习惯对生活在地中海盆地的随机老年人群体成功老龄化的炎症潜力，这些参与者均来自于 MEDIS（地中海岛屿）研究。
在 2005 年至 2016 年间，希腊 24 个地中海岛屿和农村马尼亚地区（伯罗奔尼撒半岛）的 3128 名年龄在 65-100 岁的老年人参与了该研究。采用由 10 个组成部分组成的多维成功老龄化指数。使用经过验证且可重复的食物频率问卷（FFQ）来评估老年人的饮食习惯。根据参与者的特定饮食习惯评估营养抗炎（NAI）评分。
具有高 NAI 评分（促炎营养）的参与者高胆固醇血症的患病率更高，成功老龄化的水平更低。在调整了几个混杂因素后，NAI 评分与成功老龄化相关（-0.03，95%CI-0.5 至-0.006）。按性别和高龄进行分层分析表明，NAI 评分在预测成功老龄化方面存在异质性。
营养的炎症潜力被认为是成功老龄化的一个重要因素，这表明需要进一步研究抗炎和促炎饮食习惯在健康和成功老龄化中的作用。
