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未成熟畸胎瘤罕见复发:一例报告

An uncommon recurrence of an immature teratoma: A case report.

作者信息

Li Xuelu, Zhu Dandan, Lv L I, Yu Jian

机构信息

Department of Breast Surgery, The Second Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China.

Department of Critical Care Medicine, The Second Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China.

出版信息

Oncol Lett. 2016 Apr;11(4):2453-2456. doi: 10.3892/ol.2016.4254. Epub 2016 Feb 19.

Abstract

A 24-year-old female who was previously diagnosed with an immature, right ovarian teratoma was referred to The Second Hospital of Dalian Medical University (Dalian, China) due to abdominal pain. The patient had previously undergone a laparotomy and right ovarian oophorectomy. Despite this, at 10 years post-surgery, the patient developed extensive abdominal metastases, in conjunction with elevated serum cancer antigen (CA)-125 and CA19-9 levels. The patient had a high risk of recurrence, and the liver and spleen metastases were subsequently diagnosed as mature teratomas. In order to prevent the possibility of disease recurrence, frequent post-surgical follow-up, consisting of imaging analysis and the testing of serum markers, is required. Regarding the published literature, there have been no other patients presenting with a giant teratoma with associated metastasis. Due to the lack of regular follow-up appointments in China, the tumor in the present study was not recognized until too late. Therefore, to increase the successful detection of recurrent teratomas, a longer follow-up period is necessary for patients who present with a high risk of recurrence.

摘要

一名24岁女性,此前被诊断为未成熟型右卵巢畸胎瘤,因腹痛转诊至大连医科大学附属第二医院(中国大连)。该患者此前接受过剖腹手术及右侧卵巢切除术。尽管如此,术后10年,患者出现广泛的腹部转移,并伴有血清癌抗原(CA)-125和CA19-9水平升高。该患者复发风险高,随后肝脏和脾脏转移灶被诊断为成熟畸胎瘤。为防止疾病复发,术后需要频繁进行影像学分析和血清标志物检测的随访。就已发表的文献而言,尚无其他伴有转移的巨大畸胎瘤患者。由于中国缺乏定期随访预约,本研究中的肿瘤直到很晚才被发现。因此,为提高复发性畸胎瘤的成功检出率,对于复发风险高的患者,需要更长的随访期。

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