Lorino A M, Benichou M, Kochi T, Lorino H, Milic-Emili J, Harf A
INSERM U296, Département de Physiologie, Hôpital Henri Mondor, Créteil, France.
Eur Respir J. 1989 Jan;2(1):84-9.
Assessments of total respiratory compliance (C) and conductance (G) with the constant inspiratory flow and the occlusion methods were compared in the basal state and during histamine or serotonin induced bronchoconstriction in 22 normal, anaesthetized, paralysed, mechanically ventilated guinea-pigs. In the basal state, no significant difference was found between the C and G values measured by both methods. During drug-induced bronchoconstriction, small but significant differences were observed between the respiratory parameters measured by the two methods, and expressed as the percentage ratio (R) to the corresponding basal values (respectively RCCF and RCOC, and RGCF and RGOC). This discrepancy, which was independent of the drug and of the dose, was probably attributable to a modification of the visco elastic properties of the lung due to either the mechanical ventilation or the infused drug. Nevertheless, this study demonstrates that both methods can be considered as equivalent for bronchoconstriction assessment because very strong correlations were found between RCCF and RCOC (r = 0.96, p less than 0.001) and between RGCF and RGOC (r = 0.97, p less than 0.001), and because the slopes of the linear relationships were not significantly different from unity in both cases.
在22只正常、麻醉、麻痹、机械通气的豚鼠中，比较了在基础状态以及组胺或5-羟色胺诱导支气管收缩期间，采用恒定吸气流量法和阻断法对总呼吸顺应性（C）和传导率（G）的评估。在基础状态下，两种方法测得的C和G值之间未发现显著差异。在药物诱导的支气管收缩期间，两种方法测得的呼吸参数之间观察到虽小但显著的差异，并以相对于相应基础值的百分比比值（R）表示（分别为RCCF和RCOC，以及RGCF和RGOC）。这种差异与药物和剂量无关，可能归因于机械通气或注入药物导致肺粘弹性特性的改变。然而，本研究表明，两种方法在支气管收缩评估方面可被视为等效，因为在RCCF和RCOC之间（r = 0.96，p < 0.001）以及RGCF和RGOC之间（r = 0.97，p < 0.001）发现了很强的相关性，并且因为在两种情况下线性关系的斜率与1没有显著差异。
