Dojat M, Harf A, Walton C, Macquin-Mavier I
Institut National de la Santé et de la Recherche Médicale INSERM U 296, Créteil, France.
Pflugers Arch. 1992 Feb;420(2):136-9. doi: 10.1007/BF00374981.
We built a simple high impedance ventilator, which generates a pattern of flow largely independent of respiratory mechanics, to mechanically ventilate anaesthetized small animals. The system includes a source of compressed gas with an electronic valve and a flow controller on the inspiratory side and a second valve on the expiratory side. The two valves are driven by a programmable controller. To assess the performance of this ventilator we measured the delivered tidal volume while the ventilator was connected to an external, gradually varying resistance. This resistance was progressively increased to simulate bronchoconstriction of the respiratory system. Comparison with a volume-controlled ventilator was made. The use of a programmable controller also allows control of different patterns of mechanical ventilation, such as end-inspiratory pause or the static pressure-volume relationship, which can be used to perform lung function tests. The system is a simple, versatile device allowing both reliable mechanical ventilation and lung function assessment in small rodents and is suitable for routine use in laboratories.
我们构建了一种简单的高阻抗呼吸机，它能产生一种在很大程度上独立于呼吸力学的气流模式，用于对麻醉后的小动物进行机械通气。该系统在吸气侧包括一个带有电子阀和流量控制器的压缩气体源，在呼气侧有第二个阀。这两个阀由一个可编程控制器驱动。为了评估该呼吸机的性能，我们在呼吸机连接到一个外部逐渐变化的阻力时测量了输送的潮气量。这个阻力逐渐增加以模拟呼吸系统的支气管收缩。并与容量控制呼吸机进行了比较。使用可编程控制器还可以控制不同的机械通气模式，如吸气末暂停或静态压力 - 容积关系，这可用于进行肺功能测试。该系统是一种简单、通用的设备，既可以在小型啮齿动物中实现可靠的机械通气和肺功能评估，也适用于实验室的常规使用。
