免疫系统的独特型调节。独特型与在兔中针对抗独特型抗体产生的抗体之间的共同独特型特异性。
Idiotypic regulation of the immune system. Common idiotypic specificities between idiotypes and antibodies raised against anti-idiotypic antibodies in rabbits.
作者信息
Winkler M, Franssen J D, Collignon C, Leo O, Mariamé B, van de Walle P, de Groote D, Urbain J
出版信息
J Exp Med. 1979 Jul 1;150(1):184-95. doi: 10.1084/jem.150.1.184.
Abstract
Anti-idiotypic antibodies (Ab2) were raised in allotype-matched rabbits against anti-carbohydrate or anti-tobacco mosaic virus antibodies (Ab1). Several Ab2 were purified and injected into a third series of rabbits III which synthesized antiantiidiotypic antibodies (Ab3). Antigen was then given for the first time in those rabbits who had synthesized Ab3. The specific antibody synthesized in rabbits III was called Ab1'. Anti-idiotypic antibodies were raised against purified Ab3 antibodies (Ab4). In most cases, Ab1' antibodies are sharing idiotypic specificities with Ab1. Ab3 did not react with antigen but shared idiotopes with Ab1 and Ab1' because Ab4 antibodies, which are anti-idiotypes to Ab3 do recognize specifically Ab1 and Ab1' antibodies belonging to the same chain of immunization. It seems therefore that Ab3 looks idiotypically like Ab1 and Ab4 displays the same behaviour as Ab2. A general view of the functioning of the immune system is presented.
摘要
用同种异型匹配的兔子针对抗碳水化合物或抗烟草花叶病毒抗体（Ab1）产生抗独特型抗体（Ab2）。纯化了几种Ab2并注射到第三组兔子III中，这些兔子合成了抗抗独特型抗体（Ab3）。然后在那些已经合成Ab3的兔子中首次给予抗原。在兔子III中合成的特异性抗体称为Ab1'。针对纯化的Ab3抗体（Ab4）产生抗独特型抗体。在大多数情况下，Ab1'抗体与Ab1共享独特型特异性。Ab3不与抗原反应，但与Ab1和Ab1'共享独特位，因为作为Ab3的抗独特型的Ab4抗体确实能特异性识别属于同一免疫链的Ab1和Ab1'抗体。因此，似乎Ab3在独特型上看起来像Ab1，而Ab4表现出与Ab2相同的行为。本文呈现了免疫系统功能的总体观点。
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