苏丹中部达菲阴性个体间间日疟原虫的传播
Transmission of Plasmodium vivax in Duffy-negative individuals in central Sudan.
作者信息
Abdelraheem Mohamed H, Albsheer Musab M A, Mohamed Hiba S, Amin Mutaz, Mahdi Abdel Hamid Muzamil
机构信息
Institute of Endemic Diseases, University of Khartoum, Sudan National Centre for Research Commission for Biotechnology and Genetic Engineering.
Institute of Endemic Diseases, University of Khartoum, Sudan.
出版信息
Trans R Soc Trop Med Hyg. 2016 Apr;110(4):258-60. doi: 10.1093/trstmh/trw014.
BACKGROUND
Due to the recently observed rise in Plasmodium vivax incidence in Sudan and reported transmission in Duffy-negative individuals; we aimed to assess the possibility of P. vivax transmission in Duffy-negative individuals in Gezira state, central Sudan.
METHOD
A total of 126 suspected malaria patients were diagnosed with P. vivax infection using microscopy, RDT and PCR. PCR-RFLP was used to genotype participants Duffy status.
RESULTS
Forty eight (38%) were positive for P. vivax infection by PCR. Four patients (8.3%) were homozygous Duffy-negative.
CONCLUSION
These results confirm that P. vivax can infect Duffy-negative individuals, suggesting alternative mechanisms to bind and invade erythrocytes.
背景
由于近期观察到苏丹间日疟原虫发病率上升以及有报道称在达菲阴性个体中存在传播；我们旨在评估苏丹中部杰济拉州达菲阴性个体中间日疟原虫传播的可能性。
方法
总共126名疑似疟疾患者通过显微镜检查、快速诊断检测（RDT）和聚合酶链反应（PCR）被诊断为间日疟原虫感染。采用聚合酶链反应 - 限制性片段长度多态性（PCR - RFLP）对参与者的达菲状态进行基因分型。
结果
48例（38%）通过PCR检测间日疟原虫感染呈阳性。4例患者（8.3%）为纯合子达菲阴性。
结论
这些结果证实间日疟原虫可感染达菲阴性个体，提示存在结合和侵入红细胞的替代机制。
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