来自埃塞俄比亚的 Duffy 阴性个体中的间日疟原虫疟疾。
Plasmodium vivax malaria in Duffy-negative individuals from Ethiopia.
机构信息
Department of Medical Laboratory Science, College of Medical Sciences, Haramaya University, PO Box 235, Harar, Ethiopia.
出版信息
Trans R Soc Trop Med Hyg. 2013 May;107(5):328-31. doi: 10.1093/trstmh/trt016.
BACKGROUND
This study was conducted to estimate the prevalence of Plasmodium vivax and polymorphisms in the Duffy antigen receptor for chemokines (DARC) gene in patients with suspected malaria from eastern (Harar) and southwestern (Jimma) Ethiopia.
METHODS
Plasmodium presence and species was assessed by microscopy in 1304 and 627 febrile patients in Harar and Jimma, respectively, during October-November 2009. All microscopy-positive samples were confirmed by PCR. DARC gene polymorphisms were identified by DNA sequencing.
RESULTS
Plasmodium vivax was the dominant species in Harar (74/98, 76%) and P. falciparum was more common in Jimma (70/107, 65%). We found 17/98 (17%) and 24/107 (22%) homozygous Duffy-negative patients in Harar and Jimma, respectively. Unexpectedly, three Duffy-negative patients from Harar had P. vivax malaria.
CONCLUSION
This study documents the emergence of P. vivax malaria in Duffy-negative individuals in Ethiopia. The Duffy-negative blood group does not appear to provide absolute protection against P. vivax infection in this region.
背景
本研究旨在评估来自埃塞俄比亚东部（哈拉尔）和西南部（吉马）疑似疟疾患者中恶性疟原虫和趋化因子受体（DARC）基因多态性的流行率。
方法
2009 年 10 月至 11 月，分别在哈拉尔和吉马对 1304 名和 627 名发热患者进行了显微镜检查，以评估疟原虫的存在和种类。所有显微镜阳性样本均通过 PCR 进行确认。通过 DNA 测序鉴定 DARC 基因多态性。
结果
恶性疟原虫是哈拉尔（74/98，76%）的主要物种，而吉马（70/107，65%）中更常见的是恶性疟原虫。我们分别在哈拉尔和吉马发现了 17/98（17%）和 24/107（22%）的纯合子 Duffy 阴性患者。出人意料的是，哈拉尔的 3 名 Duffy 阴性患者患有恶性疟原虫疟疾。
结论
本研究记录了恶性疟原虫在埃塞俄比亚 Duffy 阴性个体中的出现。在该地区，Duffy 阴性血型似乎并不能提供对恶性疟原虫感染的绝对保护。
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