人类和动物源致病性密螺旋体基因组的比较。
Comparison of the genomes of pathogenic treponemes of human and animal origin.
作者信息
de Wergifosse P, Coene M M
机构信息
Microbiology and Genetics Unit, ICP, University of Louvain, Brussels, Belgium.
出版信息
Infect Immun. 1989 May;57(5):1629-31. doi: 10.1128/iai.57.5.1629-1631.1989.
The aim of this study was to compare the genomes of two strains of intestinal treponemes, which were isolated from patients suffering from intestinal disorders, with that of Treponema hyodysenteriae, the known etiological agent of swine dysentery (bloody scours). The guanine-plus-cytosine contents of the three DNAs were found to be 28.5 to 30.0%. DNA-DNA hybridization in liquid phase indicated a high degree of homology (56 to 95%) among the human strains and with T. hyodysenteriae. One of the human strains in particular displayed a very high homology (91 to 95%) with T. hyodysenteriae. The overall conclusion is that treponemal strains pathogenic for humans and animals are clustered within the same species (we propose T. hyodysenteriae), which suggests the possibility of exchange of pathogenic microorganisms between domestic animals and humans.
本研究的目的是将从患有肠道疾病的患者中分离出的两株肠道密螺旋体的基因组与猪痢疾（血性腹泻）的已知病原体猪痢疾密螺旋体的基因组进行比较。发现这三种DNA的鸟嘌呤加胞嘧啶含量为28.5%至30.0%。液相DNA-DNA杂交表明，这些人类菌株之间以及与猪痢疾密螺旋体之间具有高度同源性（56%至95%）。其中一株人类菌株与猪痢疾密螺旋体表现出非常高的同源性（91%至95%）。总体结论是，对人和动物致病的密螺旋体菌株聚集在同一物种内（我们提议为猪痢疾密螺旋体），这表明家畜和人类之间可能存在致病微生物的交换。
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