荷兰长期前往热带地区旅行者中的流感：症状与感染情况
Influenza in long-term Dutch travelers in the tropics: symptoms and infections.
作者信息
Whelan Jane, Rimmelzwaan Guus F, van den Hoek Anneke, Belderok Sanne-Meike, Sonder Gerard J B
机构信息
Department of Infectious Diseases, Public Health Service Amsterdam, Nieuwe Achtergracht 100, 1018WT, Amsterdam, The Netherlands.
Erasmus Medical Center, Rotterdam, The Netherlands.
出版信息
BMC Infect Dis. 2016 Apr 16;16:158. doi: 10.1186/s12879-016-1502-6.
BACKGROUND
Influenza is a common infection among travelers, and attack rates are well documented in short-term travelers and holiday makers. Little data exists on long-term, non-expatriate travelers.
METHODS
This was a prospective mono-centre study of immunocompetent, Dutch travelers aged ≥18 to 64 years. It was conducted at the Public Health Service travel clinic in Amsterdam from December 2008 to September 2011, and included all travelers intending to travel to a tropical or sub-tropical country.
RESULTS
Among 602 Dutch long-term travelers to tropical regions, 82 % had protective influenza antibody titres pre-travel. The influenza attack rate of serologically confirmed infection during travel was 15 %, and of symptomatic infection was 6.3 % (fever alone) and 2 % (ILI), respectively.
CONCLUSIONS
The attack rate in this study is similar to seasonal rates of infection in the general population. Influenza vaccination pre-travel is therefore most important for people at risk of medical complications due to influenza.
背景
流感是旅行者中的常见感染，短期旅行者和度假者的发病率已有充分记录。关于长期非侨居旅行者的数据很少。
方法
这是一项针对年龄在18至64岁之间、免疫功能正常的荷兰旅行者的前瞻性单中心研究。该研究于2008年12月至2011年9月在阿姆斯特丹的公共卫生服务旅行诊所进行，纳入了所有打算前往热带或亚热带国家旅行的旅行者。
结果
在602名前往热带地区的荷兰长期旅行者中，82%在旅行前具有保护性流感抗体滴度。旅行期间血清学确诊感染的流感发病率为15%，有症状感染的发病率分别为6.3%（仅发热）和2%（流感样疾病）。
结论
本研究中的发病率与普通人群的季节性感染率相似。因此，对于有因流感导致医疗并发症风险的人群，旅行前接种流感疫苗最为重要。
Zotero 插件