Bodell Lindsay P, Racine Sarah E, Wildes Jennifer E
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213.
Department of Psychology, Ohio University, Athens, OH, 45701.
Int J Eat Disord. 2016 Aug;49(8):753-63. doi: 10.1002/eat.22545. Epub 2016 Apr 16.
Research in individuals with bulimia nervosa has highlighted the clinical significance of weight suppression (WS), defined as the difference between one's highest and current weight. More recently, studies have suggested that WS also may play a role in symptom maintenance and weight gain during treatment in anorexia nervosa (AN) and that the influence of WS on AN outcomes may depend on an individual's body mass index (BMI). However, no study has investigated whether WS or the interaction between WS and BMI is associated with the longer-term course of eating pathology following treatment discharge in patients with AN.
The current study examined a sample of females with AN (N = 180) who completed interviews and self-report questionnaires at discharge from intensive treatment and at 3, 6, and 12-months after discharge. Latent growth curve models tested whether WS, BMI, or the WS by BMI interaction significantly predicted the trajectory of eating disorder symptoms (i.e., Eating Disorder Examination global score, BMI, frequency of loss of control eating, frequency of purging) over the year following discharge.
WS at discharge predicted change in BMI, and the interaction between WS and BMI predicted growth in eating disorder severity and purging frequency over time. Neither WS nor its interaction with BMI predicted growth in loss of control eating frequency.
Results provide further support for the clinical significance of WS in AN symptom maintenance, but suggest that the influence of WS likely depends on an individual's BMI as well as the outcome being measured. © 2016 Wiley Periodicals, Inc.(Int J Eat Disord 2016; 49:753-763).
对神经性贪食症患者的研究凸显了体重抑制(WS)的临床意义,体重抑制定义为个体最高体重与当前体重之差。最近,研究表明体重抑制在神经性厌食症(AN)治疗期间的症状维持和体重增加中也可能起作用,并且体重抑制对神经性厌食症治疗结果的影响可能取决于个体的体重指数(BMI)。然而,尚无研究调查体重抑制或体重抑制与体重指数之间的相互作用是否与神经性厌食症患者出院后饮食病理学的长期病程相关。
本研究对一组神经性厌食症女性患者(N = 180)进行了调查,这些患者在强化治疗出院时以及出院后3个月、6个月和12个月完成了访谈和自我报告问卷。潜在生长曲线模型测试了体重抑制、体重指数或体重抑制与体重指数的相互作用是否能显著预测出院后一年内饮食失调症状的轨迹(即饮食失调检查总体评分、体重指数、失控性进食频率、清除频率)。
出院时的体重抑制预测了体重指数的变化,体重抑制与体重指数之间的相互作用预测了饮食失调严重程度和清除频率随时间的增长。体重抑制及其与体重指数二者均未预测失控性进食频率的增长。
研究结果进一步支持了体重抑制在神经性厌食症症状维持中的临床意义,但表明体重抑制的影响可能取决于个体的体重指数以及所测量的结果。© 2016威利期刊公司(《国际进食障碍杂志》2016年;49:753 - 763)