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使用压力定量吸入器和干粉吸入器的哮喘患者吸入技术与哮喘控制之间的关联。

Associations between inhaler technique and asthma control among asthma patients using pressurised MDIs and DPIs.

作者信息

Basheti I A, Obeidat N M, Ammari W G, Reddel H K

机构信息

Department of Clinical Pharmacy & Therapeutics, Faculty of Pharmacy, Applied Science University, Amman, Jordan.

Department of Internal Medicine, Respiratory and Sleep Medicine, Faculty of Medicine, Jordan University Hospital, Amman, Jordan.

出版信息

Int J Tuberc Lung Dis. 2016 May;20(5):689-95. doi: 10.5588/ijtld.15.0557.

Abstract

OBJECTIVES

To investigate associations between technique with pressurised metered-dose inhalers (pMDIs) and dry powder inhalers (DPIs) used as controller medication and asthma control variables measured using Asthma Control Test (ACT) scores.

DESIGN

In this cross-sectional study, the inhaler technique of asthma patients using pMDIs or DPIs (Turbuhaler® [TH] and Accuhaler Diskus™ [ACC]) were assessed against published inhaler technique checklists. ACT scores (maximum 25, higher score corresponding to better asthma control) were assessed.

RESULTS

Of the 130 subjects enrolled in the study (41 TH, 54 ACC and 35 pMDI), inhaler technique scores (out of nine for all devices) were low for TH (4.4 ± 0.9) and ACC (5.4 ± 1.0) compared with pMDI (8.1 ± 0.9) (P < 0.001, one-way analysis of variance). Older age and use of pMDI were associated with better inhaler technique. ACT scores were low, consistent with very poorly controlled asthma (mean TH 13.1 ± SD 3.9, mean ACC 13.3 ± SD 3.9 and mean pMDI 12.8 ± SD 4.2). No significant association between inhaler technique scores and ACT scores was found. More recent asthma diagnosis and a higher level of education were associated with higher ACT scores (better asthma control).

CONCLUSION

Asthma control was poor in this population. Lack of a significant association between the inhaler technique score and asthma control may reflect the multiple factors contributing to poor asthma control in the Jordanian population.

摘要

目的

研究使用压力定量吸入器(pMDIs)和干粉吸入器(DPIs)作为控制药物的技术与使用哮喘控制测试(ACT)分数测量的哮喘控制变量之间的关联。

设计

在这项横断面研究中,根据已发表的吸入器技术检查表,对使用pMDIs或DPIs(都保® [TH]和准纳器™ [ACC])的哮喘患者的吸入器技术进行评估。评估ACT分数(最高25分,分数越高表明哮喘控制越好)。

结果

在该研究纳入的130名受试者中(41名使用TH,54名使用ACC,35名使用pMDI),与pMDI(8.1±0.9)相比,TH(4.4±0.9)和ACC(5.4±1.0)的吸入器技术得分(满分9分)较低(P<0.001,单因素方差分析)。年龄较大和使用pMDI与更好的吸入器技术相关。ACT分数较低,与哮喘控制非常差一致(TH组平均13.1±标准差3.9,ACC组平均13.3±标准差3.9,pMDI组平均12.8±标准差4.2)。未发现吸入器技术得分与ACT分数之间存在显著关联。最近的哮喘诊断和较高的教育水平与较高的ACT分数(更好的哮喘控制)相关。

结论

该人群的哮喘控制较差。吸入器技术得分与哮喘控制之间缺乏显著关联可能反映了约旦人群中导致哮喘控制不佳的多种因素。

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