Impact of slow K(+) currents on spike generation can be described by an adaptive threshold model.

A neuron that is stimulated by rectangular current injections initially responds with a high firing rate, followed by a decrease in the firing rate. This phenomenon is called spike-frequency adaptation and is usually mediated by slow K(+) currents, such as the M-type K(+) current (I M ) or the Ca(2+)-activated K(+) current (I AHP ). It is not clear how the detailed biophysical mechanisms regulate spike generation in a cortical neuron. In this study, we investigated the impact of slow K(+) currents on spike generation mechanism by reducing a detailed conductance-based neuron model. We showed that the detailed model can be reduced to a multi-timescale adaptive threshold model, and derived the formulae that describe the relationship between slow K(+) current parameters and reduced model parameters. Our analysis of the reduced model suggests that slow K(+) currents have a differential effect on the noise tolerance in neural coding.