Shrestha Srishti, Lutsey Pamela L, Alonso Alvaro, Huang Xuemei, Mosley Thomas H, Chen Honglei
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Mov Disord. 2016 Jul;31(7):972-8. doi: 10.1002/mds.26573. Epub 2016 Apr 19.
Low vitamin D levels are common among patients with Parkinson's disease (PD). Experimental evidence further suggests that vitamin D may be protective against PD. The objective of this study was to prospectively assess the association between serum 25-hydroxyvitamin D and PD among 12,762 participants of the Atherosclerosis Risk in Communities Study cohort.
Serum samples were collected in 1990-1992, and 25-hydroxyvitamin D was measured by liquid chromatography mass spectrometry. A total of 67 incident PD cases were identified through December 31, 2008. The median length of follow-up was 17 years. We used Cox proportional hazards models to obtain hazard ratios and 95% confidence intervals, adjusting for age, sex, and race. We did not find any association between serum 25-hydroxyvitamin D concentrations and PD risk, regardless of how serum 25-hydroxyvitamin D was modeled. Compared with participants with serum 25-hydroxyvitamin D < 20 ng/mL, the hazards ratio for PD was 1.05 (95% confidence interval, 0.58-1.90) for 20-30 ng/mL and 1.14 (95% confidence interval, 0.59- 2.23) for ≥30 ng/mL. Similar results were obtained in sensitivity analyses that included white participants only and that were stratified by the length of follow-up.
This prospective study lends no support to the hypothesis that vitamin D may reduce the risk of PD. © 2016 International Parkinson and Movement Disorder Society.
帕金森病（PD）患者中维生素D水平低很常见。实验证据进一步表明维生素D可能对PD有保护作用。本研究的目的是前瞻性评估社区动脉粥样硬化风险研究队列的12762名参与者中血清25-羟维生素D与PD之间的关联。
于1990 - 1992年收集血清样本，采用液相色谱质谱法测定25-羟维生素D。截至2008年12月31日共确定67例新发PD病例。中位随访时间为17年。我们使用Cox比例风险模型获得风险比和95%置信区间，并对年龄、性别和种族进行了调整。无论血清25-羟维生素D如何建模，我们均未发现血清25-羟维生素D浓度与PD风险之间存在任何关联。与血清25-羟维生素D<20 ng/mL的参与者相比。血清25-羟维生素D为20 - 30 ng/mL时PD的风险比为1.05（95%置信区间，0.58 - 1.90），≥30 ng/mL时为1.14（95%置信区间，0.59 - 2.23）。在仅纳入白人参与者并按随访时间分层的敏感性分析中也获得了类似结果。
这项前瞻性研究不支持维生素D可降低PD风险这一假说。© 2016国际帕金森和运动障碍协会。
