Berninger Benedikt, Jessberger Sebastian
Adult Neurogenesis and Cellular Reprogramming, Institute of Physiological Chemistry & Focus Program Translational Neuroscience, University Medical Center, Johannes Gutenberg University Mainz, 55128 Mainz, Germany.
Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland.
Cold Spring Harb Perspect Biol. 2016 May 2;8(5):a018861. doi: 10.1101/cshperspect.a018861.
Neural stem/progenitor cells (NSPCs) retain their ability to generate newborn neurons throughout life in the mammalian brain. Here, we describe how recently developed virus- and transgenesis-based techniques will help us (1) to understand the functional effects of neurogenesis in health and disease, (2) to design novel approaches to harness the potential for NSPC-associated endogenous repair, and (3) to induce the generation of neurons outside the main neurogenic niches in the adult brain.
神经干细胞/祖细胞（NSPCs）在哺乳动物大脑中终生保留产生新生神经元的能力。在此，我们描述了最近基于病毒和转基因的技术将如何帮助我们：（1）了解神经发生在健康和疾病中的功能作用；（2）设计新方法以利用NSPC相关内源性修复的潜力；（3）诱导成人大脑主要神经发生微环境之外的神经元生成。
